Gudjohnsen Stefán A H, Atacho Diahann A M, Gesbert Franck, Raposo Graca, Hurbain Ilse, Larue Lionel, Steingrimsson Eirikur, Petersen Petur Henry
Faculty of Medicine, Department of Anatomy, Biomedical Center, University of Iceland Reykjavik, Iceland ; Faculty of Medicine, Department of Biochemistry and Molecular Biology, Biomedical Center, University of Iceland Reykjavik, Iceland.
Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes Orsay, France ; Université Paris-Sud, Université Paris-Saclay, CNRS UMR 3347 Orsay, France ; Equipe Labellisée Ligue Contre le Cancer Orsay, France.
Front Neuroanat. 2015 Nov 25;9:149. doi: 10.3389/fnana.2015.00149. eCollection 2015.
Melanocytes are pigment producing cells derived from the neural crest. They are primarily found in the skin and hair follicles, but can also be found in other tissues including the eye, ear and heart. Here, we describe the distribution of pigmented cells in C57BL/6J mouse meninges, the membranes that envelope the brain. These cells contain melanosomes of all four stages of development and they depend on Microphthalmia associated transcription factor (MITF), the master regulator of melanocyte development, suggesting that they are bona-fide melanocytes. The location of these pigmented cells is consistent with the location of meningeal melanomas in humans and animal models.
Here, we document and define pigmented cells in the meninges of the mouse brain and confirm that they are melanocytes. This is important for understanding the role of this cell type and for understanding primary meningeal melanoma, a rare disease that likely arises from normal meningeal melanocytes.
黑素细胞是源自神经嵴的色素生成细胞。它们主要存在于皮肤和毛囊中，但也可在包括眼睛、耳朵和心脏在内的其他组织中发现。在此，我们描述了C57BL/6J小鼠脑膜（包裹大脑的膜）中色素细胞的分布。这些细胞含有所有四个发育阶段的黑素小体，并且它们依赖小眼相关转录因子（MITF），即黑素细胞发育的主要调节因子，这表明它们是真正的黑素细胞。这些色素细胞的位置与人类和动物模型中脑膜黑色素瘤的位置一致。
在此，我们记录并定义了小鼠脑膜中的色素细胞，并证实它们是黑素细胞。这对于理解这种细胞类型的作用以及理解原发性脑膜黑色素瘤（一种可能起源于正常脑膜黑素细胞的罕见疾病）很重要。
