布朗斯特酸-路易斯碱协同催化剂促进的α-氧代酯的对映选择性氰基-烷氧基羰基化反应
Enantioselective Cyano-Alkoxycarbonylation of α-Oxoesters Promoted by Brønsted Acid-Lewis Base Cooperative Catalysts.
作者信息
Ishihara Kazuaki, Ogura Yoshihiro
机构信息
Graduate School of Engineering, Nagoya University , B2-3(611), Furo-cho, Chikusa, Nagoya 464-8603, Japan.
出版信息
Org Lett. 2015 Dec 18;17(24):6070-3. doi: 10.1021/acs.orglett.5b03093. Epub 2015 Dec 4.
PMID:26636610
Abstract
The highly enantioselective cyano-alkoxycarbonylation of α-oxoesters with alkyl cyanoformates is promoted by a new chiral Brønsted acid-Lewis base cooperative organocatalyst. The present catalysis can be performed at room temperature under nitrogen or air.
摘要
一种新型手性布朗斯特酸-路易斯碱协同有机催化剂可促进α-氧代酯与氰基甲酸烷基酯的高度对映选择性氰基-烷氧基羰基化反应。目前的催化反应可在氮气或空气氛围下于室温进行。
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