原发性子宫切除术或保留生育功能治疗的非典型子宫内膜增生患者的癌症发病率
Cancer Incidence in Patients with Atypical Endometrial Hyperplasia Managed by Primary Hysterectomy or Fertility-sparing Treatment.
作者信息
Gonthier Clémentine, Piel Bruno, Touboul Cyril, Walker Francine, Cortez Annie, Luton Dominique, Daraï Emile, Koskas Martin
机构信息
Department of Obstetrics and Gynecology, Bichat University Hospital, Paris, France.
Department of Obstetrics and Gynecology, Tenon University Hospital, Paris, France.
出版信息
Anticancer Res. 2015 Dec;35(12):6799-804.
AIM
To compare the risk of developing endometrial carcinoma (EC) in young women with atypical endometrial hyperplasia (AEH) undergoing fertility-sparing management compared to women treated by primary hysterectomy.
PATIENTS AND METHODS
In this multicentric retrospective study, 111 patients with a diagnosis of AEH by endometrial biopsy were included. EC incidence was compared in two groups: 32 patients treated with fertility-sparing management and 79 older patients treated with primary hysterectomy.
RESULTS
The rates of EC diagnosed by pathology of hysterectomy specimens were comparable between the groups. The probability of developing EC at 12, 24 and 36 months were 14%, 21% and 26%, respectively, in patients managed conservatively, and 29%, 37% and 37%, respectively, in patients treated with primary hysterectomy.
CONCLUSION
Fertility-sparing management of AEH does not increase the risk of diagnosing EC from the hysterectomy specimen.
目的
比较接受保留生育功能治疗的非典型子宫内膜增生（AEH）年轻女性与接受原发性子宫切除术治疗的女性发生子宫内膜癌（EC）的风险。
患者与方法
在这项多中心回顾性研究中，纳入了111例经子宫内膜活检诊断为AEH的患者。比较两组的EC发生率：32例接受保留生育功能治疗的患者和79例接受原发性子宫切除术治疗的老年患者。
结果
两组间子宫切除标本病理诊断的EC发生率相当。保守治疗患者在12个月、24个月和36个月时发生EC的概率分别为14%、21%和26%，接受原发性子宫切除术治疗的患者分别为29%、37%和37%。
结论
AEH的保留生育功能治疗不会增加子宫切除标本诊断EC的风险。
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