Puttabyatappa Muraly, Cardoso Rodolfo C, Padmanabhan Vasantha
Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.
Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.
Mol Cell Endocrinol. 2016 Nov 5;435:29-39. doi: 10.1016/j.mce.2015.11.030. Epub 2015 Nov 27.
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder with both reproductive and metabolic abnormalities affecting women of reproductive age. While the exact origin of PCOS is unknown, observations from clinical and animal studies suggest that maternal hyperandrogenism may be a contributing factor. Because women with PCOS manifest hyperandrogenism during pregnancy, changes in the gestational endocrine milieu may play a role in the vertical transmission of this syndrome. This review discusses the potential developmental origins of PCOS, the impact of maternal PCOS on the offspring's health and contributions of the postnatal environment, capitalizing on findings from animal models that exhibit a PCOS-like phenotype. In addition, this review highlights the scarcity of data at early gestational stages in humans and the importance of animal experimentation to better understand the cellular and molecular mechanisms involved in the programming of adult diseases, therefore, helping identify therapeutic targets for preventive and treatment strategies.
多囊卵巢综合征（PCOS）是一种异质性内分泌疾病，伴有生殖和代谢异常，影响育龄女性。虽然PCOS的确切起源尚不清楚，但临床和动物研究的观察结果表明，母体高雄激素血症可能是一个促成因素。由于患有PCOS的女性在孕期表现出高雄激素血症，妊娠期内分泌环境的变化可能在该综合征的垂直传播中起作用。本综述讨论了PCOS潜在的发育起源、母体PCOS对后代健康的影响以及产后环境的作用，借鉴了表现出PCOS样表型的动物模型的研究结果。此外，本综述强调了人类妊娠早期阶段数据的匮乏，以及动物实验对于更好地理解成人疾病编程所涉及的细胞和分子机制的重要性，从而有助于确定预防和治疗策略的治疗靶点。
