司可巴比妥人体代谢研究。

A study of the human metabolism of secbutobarbitone.

作者信息

Gilbert J N, Powell J W, Templeton J

出版信息

J Pharm Pharmacol. 1975 Dec;27(12):923-7. doi: 10.1111/j.2042-7158.1975.tb10249.x.

DOI:10.1111/j.2042-7158.1975.tb10249.x

Abstract

The urinary excretion of secbutobarbitone (I) and its metabolites has been studied quantitatively using combined gas chromatography-mass spectrometry. After a single oral dose was given to healthy male volunteers, unchanged drug (5-9%), 2'-hydroxysecbutobarbitone (II, 1.7-3.2%), 2'-oxosecbutobarbitone (III, less than 1%), and the carboxylic acid (IV, 24-34%) were found. The kinetics of the excretion process were studied.

摘要

已使用气相色谱 - 质谱联用法定量研究了仲丁巴比妥（I）及其代谢产物的尿排泄情况。给健康男性志愿者单次口服给药后，检测到了未变化的药物（5 - 9%）、2'-羟基仲丁巴比妥（II，1.7 - 3.2%）、2'-氧代仲丁巴比妥（III，小于1%）以及羧酸（IV，24 - 34%）。研究了排泄过程的动力学。