Bittner G D
Department of Zoology, College of Pharmacy, University of Texas, Austin 78712.
J Neurobiol. 1989 Jul;20(5):386-408. doi: 10.1002/neu.480200510.
The crayfish opener neuromuscular preparation exhibits most of the plasticities yet described for any synapse, including facilitation, long-term potentiation, presynaptic inhibition, and modulation. Since the presynaptic terminals and postsynaptic muscle fibers can both be intracellularly penetrated, one can now more easily examine the cellular/molecular bases for these plasticities. Data from such studies suggest that facilitation may be influenced by something other than residual free calcium and that presynaptic inhibition is produced by a conductance increase to chloride in the terminals of the excitor axon. Several drugs (ethanol, pentobarbital) have significant effects on these synaptic plasticities over concentration ranges which produce obvious behavioral effects in crayfish and mammals. Hence, this preparation should be a useful model system to determine cellular/molecular bases for various synaptic plasticities and the effects of drugs on these plasticities.
小龙虾开肌神经肌肉标本展现出了迄今所描述的任何突触所具有的大多数可塑性，包括易化、长时程增强、突触前抑制和调制。由于突触前终末和突触后肌纤维都能被细胞内穿刺，现在人们可以更轻松地研究这些可塑性的细胞/分子基础。此类研究的数据表明，易化可能受残余游离钙以外的因素影响，且突触前抑制是由兴奋轴突终末中氯离子电导增加所产生的。几种药物（乙醇、戊巴比妥）在产生小龙虾和哺乳动物明显行为效应的浓度范围内，对这些突触可塑性有显著影响。因此，该标本应是一个有用的模型系统，可用于确定各种突触可塑性的细胞/分子基础以及药物对这些可塑性的影响。
