利用（S）-3,3'-二溴-1,1'-联萘酚作为手性溶剂，高效测定黄烷酮对映体纯度和绝对构型。
Efficient Determination of the Enantiomeric Purity and Absolute Configuration of Flavanones by Using (S)-3,3'-Dibromo-1,1'-bi-2-naphthol as a Chiral Solvating Agent.
机构信息
School of Pharmacy, Shanghai University of Traditional Chinese Medicine , 1200 Cailun Road, Shanghai, 201203, People's Republic of China.
CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Shanghai, 201203, People's Republic of China.
出版信息
J Nat Prod. 2015 Dec 24;78(12):2968-74. doi: 10.1021/acs.jnatprod.5b00690. Epub 2015 Dec 7.
The enantiomeric purity and absolute configuration of flavanones were first determined using (S)-3,3'-dibromo-1,1'-bi-2-naphthol as a chiral solvating agent by means of (1)H NMR spectroscopy. The enantiomeric purity results closely matched those based on chiral HPLC analysis.
首次采用（S）-3,3′-二溴-1,1′-联萘-2-酚作为手性溶剂，通过 1H NMR 光谱法测定了黄烷酮的对映体纯度和绝对构型。对映体纯度的结果与基于手性 HPLC 分析的结果非常吻合。
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