通过手性联萘硼酸酯的核磁共振法对α-和β-羟基酸的绝对构型进行管测定。

In tube determination of the absolute configuration of alpha- and beta-hydroxy acids by NMR via chiral BINOL borates.

作者信息

Freire Félix, Quiñoá Emilio, Riguera Ricardo

机构信息

Departamento de Química Orgánica, Universidad de Santiago de Compostela, E-15782, Santiago de Compostela, Spain.

出版信息

Chem Commun (Camb). 2008 Sep 21(35):4147-9. doi: 10.1039/b806529b. Epub 2008 Jul 14.

DOI:10.1039/b806529b

PMID:18802511

Abstract

A simple NMR methodology, through the formation of chiral BINOL borates in the NMR tube, and that reunites the advantages of chiral derivatizing (CDAs) and chiral solvating agents (CSAs), is presented for the assignment of the absolute configuration of alpha- and beta-hydroxy acids.

摘要

本文介绍了一种简单的核磁共振方法，通过在核磁共振管中形成手性联萘硼酸酯，该方法兼具手性衍生化试剂（CDA）和手性溶剂化剂（CSA）的优点，用于确定α-和β-羟基酸的绝对构型。