Implications for the future of the HIV epidemic if drug resistance against dolutegravir cannot occur in first-line therapy.
作者信息
Wainberg Mark A, Mesplede Thibault
机构信息
McGill University AIDS Centre, Jewish General Hospital, Montreal, QC, Canada;
McGill University AIDS Centre, Jewish General Hospital, Montreal, QC, Canada.
出版信息
J Int AIDS Soc. 2015 Dec 4;18(1):20824. doi: 10.7448/IAS.18.1.20824. eCollection 2015.
Abstract
摘要
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Implications for the future of the HIV epidemic if drug resistance against dolutegravir cannot occur in first-line therapy.如果一线治疗中不会出现对多替拉韦的耐药性，对HIV流行趋势未来的影响。
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Dolutegravir-lamivudine as initial therapy in HIV-1 infected, ARV-naive patients, 48-week results of the PADDLE (Pilot Antiretroviral Design with Dolutegravir LamivudinE) study.多替拉韦-拉米夫定作为初治的HIV-1感染且未接受抗逆转录病毒治疗患者的初始治疗方案：PADDLE（多替拉韦-拉米夫定先导抗逆转录病毒设计）研究的48周结果
J Int AIDS Soc. 2017 May 9;20(1):21678. doi: 10.7448/IAS.20.01.21678.
2
Hit me with your best shot: dolutegravir - a space in the next WHO guidelines?向我发起最有力的一击：多替拉韦——在世卫组织的下一轮指南中会有一席之地吗？
AIDS. 2015 Oct 23;29(16):2067-70. doi: 10.1097/QAD.0000000000000813.
3
Resistance against Integrase Strand Transfer Inhibitors and Relevance to HIV Persistence.对整合酶链转移抑制剂的耐药性及其与HIV持续存在的相关性。
Viruses. 2015 Jul 7;7(7):3703-18. doi: 10.3390/v7072790.
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In vitro activity of dolutegravir against wild-type and integrase inhibitor-resistant HIV-2.多替拉韦对野生型和整合酶抑制剂耐药HIV-2的体外活性。
Retrovirology. 2015 Feb 5;12:10. doi: 10.1186/s12977-015-0146-8.
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Dolutegravir in HIV-2-Infected Patients With Resistant Virus to First-line Integrase Inhibitors From the French Named Patient Program.法国患者计划中一线整合酶抑制剂耐药的 HIV-2 感染者使用度鲁特韦的情况。
Clin Infect Dis. 2015 May 15;60(10):1521-7. doi: 10.1093/cid/civ124. Epub 2015 Feb 17.
6
Differential effects of the G118R, H51Y, and E138K resistance substitutions in different subtypes of HIV integrase.HIV整合酶不同亚型中G118R、H51Y和E138K耐药性替代的差异效应
J Virol. 2015 Mar;89(6):3163-75. doi: 10.1128/JVI.03353-14. Epub 2014 Dec 31.
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Dolutegravir versus placebo in subjects harbouring HIV-1 with integrase inhibitor resistance associated substitutions: 48-week results from VIKING-4, a randomized study.多替拉韦与安慰剂在携带具有整合酶抑制剂耐药相关替代位点的HIV-1感染者中的比较：随机研究VIKING-4的48周结果
Antivir Ther. 2015;20(3):343-8. doi: 10.3851/IMP2878. Epub 2014 Oct 16.
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Once-daily dolutegravir versus darunavir plus ritonavir in antiretroviral-naive adults with HIV-1 infection (FLAMINGO): 48 week results from the randomised open-label phase 3b study.在初治 HIV-1 感染的成人中，每日一次多替拉韦与达芦那韦/利托那韦比较（FLAMINGO）：随机、开放标签、3b 期研究的 48 周结果。
Lancet. 2014 Jun 28;383(9936):2222-31. doi: 10.1016/S0140-6736(14)60084-2. Epub 2014 Apr 1.
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Dolutegravir in antiretroviral-experienced patients with raltegravir- and/or elvitegravir-resistant HIV-1: 24-week results of the phase III VIKING-3 study.多替拉韦用于既往接受抗逆转录病毒治疗且对拉替拉韦和/或埃替拉韦耐药的HIV-1患者：III期VIKING-3研究的24周结果
J Infect Dis. 2014 Aug 1;210(3):354-62. doi: 10.1093/infdis/jiu051. Epub 2014 Jan 19.
10
What if HIV were unable to develop resistance against a new therapeutic agent?如果 HIV 无法对新的治疗药物产生耐药性，会怎样？
BMC Med. 2013 Nov 22;11:249. doi: 10.1186/1741-7015-11-249.
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