Kojima S, Fukuda M, Horibe K, Matsuyama T, Takeyama K, Matsushita T, Miyamura K, Sugihara T, Minami S, Kodera Y
Rinsho Ketsueki. 1989 Feb;30(2):175-80.
Thirty two patients with hematologic malignancies and solid tumors were treated with intensive therapy and autologous bone marrow transplantation. In nine out of 32 patients, it took more than 50 days to achieve a sustained platelet count of 50,000/microliter or greater. Significant associations with poor platelet recovery were found for patient age, diseases, period of cryopreservation, the kinds of eradicative therapy and in vitro purging. But most of these factors overlapped each other in the same patients. No correlation was found between platelet recovery and number of cells or CFU-GM infused.
32例血液系统恶性肿瘤和实体瘤患者接受了强化治疗和自体骨髓移植。32例患者中有9例需要50多天才能使血小板计数持续达到50,000/微升或更高。发现患者年龄、疾病、冷冻保存时间、根除性治疗种类和体外净化与血小板恢复不良存在显著关联。但在同一患者中，这些因素大多相互重叠。未发现血小板恢复与输入的细胞数量或CFU-GM之间存在相关性。
