Yoon Jong Hyun, Nam Youngwon, Song Eun Young, Roh Eun Youn, Yoon Hyun-Sun, Shin Sue
Clin Lab. 2015;61(10):1577-80. doi: 10.7754/clin.lab.2015.150311.
Recently, CC chemokine ligand28 (CCL28) has been reported as a severity marker in atopic dermatitis. We studied the association between objectively observed lesions and the level of CCL28 in children patients.
A total of 105 children patients were grouped by the objective Scoring Atopic Dermatitis index (SCORAD). Total IgE, specific IgE, complete blood count, and serum level of CCL28 were evaluated.
The mean age of the subjects was 5.3 (range, 0 - 12 years). The median SCORAD was 21.4 and consisted of mild 70%, moderate 25%, and severe 6% disease. There were no statistical differences among severity groups for CCL28 or for total IgE. Total IgE showed positive correlation with eosinophil count (r = 0.429, p < 0.01), and SCORAD (r = 0.210, p < 0.05).
The disease severity of atopic dermatitis in children is not correlated to the level of CCL28, but rather related to that of total IgE.
最近，CC趋化因子配体28（CCL28）已被报道为特应性皮炎的严重程度标志物。我们研究了儿童患者客观观察到的皮损与CCL28水平之间的关联。
根据客观特应性皮炎评分指数（SCORAD）对105例儿童患者进行分组。评估总IgE、特异性IgE、全血细胞计数和CCL28血清水平。
受试者的平均年龄为5.3岁（范围0 - 12岁）。SCORAD中位数为21.4，其中轻度疾病占70%，中度疾病占25%，重度疾病占6%。CCL28或总IgE在严重程度组之间无统计学差异。总IgE与嗜酸性粒细胞计数呈正相关（r = 0.429，p < 0.01），与SCORAD呈正相关（r = 0.210，p < 0.05）。
儿童特应性皮炎的疾病严重程度与CCL28水平无关，而与总IgE水平有关。
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