泰国耐甲氧西林中间葡萄球菌中新型复合葡萄球菌盒式染色体mec的特征分析
Characterization of a Novel Composite Staphylococcal Cassette Chromosome mec in Methicillin-Resistant Staphylococcus pseudintermedius from Thailand.
作者信息
Chanchaithong Pattrarat, Prapasarakul Nuvee, Perreten Vincent, Schwendener Sybille
机构信息
Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Bern, Switzerland Department of Veterinary Microbiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
Department of Veterinary Microbiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
出版信息
Antimicrob Agents Chemother. 2015 Dec 7;60(2):1153-7. doi: 10.1128/AAC.02268-15. Print 2016 Feb.
Abstract
A novel staphylococcal cassette chromosome mec (SCCmec) composite island (SCCmecAI16-SCCczrAI16-CI) was identified in Staphylococcus pseudintermedius. Four integration site sequences for SCC subdivided the 60,734-bp island into 41,232-bp SCCmecAI16, 19,400-bp SCCczrAI16, and 102-bp SCC-likeAI16 elements. SCCmecAI16 represents a new combination of ccrA1B3 genes with a class A mec complex. SCCczrAI16 contains ccrA1B6 and genes related to restriction modification and heavy metal resistance. SCCmecAI16-SCCczrAI16-CI was found in methicillin-resistant S. pseudintermedius sequence type 112 (ST112) and ST111 isolated from dogs and veterinarians in Thailand.
摘要
在中间葡萄球菌中鉴定出一种新型葡萄球菌盒式染色体mec（SCCmec）复合岛（SCCmecAI16 - SCCczrAI16 - CI）。SCC的四个整合位点序列将这个60,734碱基对的岛分为41,232碱基对的SCCmecAI16、19,400碱基对的SCCczrAI16和102碱基对的SCC样AI16元件。SCCmecAI16代表ccrA1B3基因与A类mec复合体的新组合。SCCczrAI16包含ccrA1B6以及与限制修饰和重金属抗性相关的基因。SCCmecAI16 - SCCczrAI16 - CI在从泰国的狗和兽医中分离出的耐甲氧西林中间葡萄球菌序列类型112（ST112）和ST111中被发现。
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