Matheson Rebecca, Moses-Burton Suzette, Hsieh Amy C, Dilmitis Sophie, Happy Margaret, Sinyemu Eunice, Brion Sophie O, Sharma Aditi
International Community of Women Living with HIV (ICW), Nairobi, Kenya.
Global Network of People Living with HIV (GNP+), Amsterdam, The Netherlands.
J Int AIDS Soc. 2015 Dec 1;18(Suppl 5):20286. doi: 10.7448/IAS.18.6.20286. eCollection 2015.
In 2011, the Global Plan towards the Elimination of New HIV Infections among Children by 2015 and Keeping Their Mothers Alive was launched to scale up efforts to comprehensively end vertical HIV transmission and support mothers living with HIV in remaining healthy. Amidst excitement around using treatment as prevention, Malawi's Ministry of Health conceived Option B+, a strategy used to prevent vertical transmission by initiating all pregnant and breastfeeding women living with HIV on lifelong antiretroviral therapy, irrespective of CD4 count. In 2013, for programmatic and operational reasons, the WHO officially recommended Option B+ to countries with generalized epidemics, limited access to CD4 testing, limited partner testing, long breastfeeding duration or high fertility rates.
While acknowledging the opportunity to increase treatment access globally and its potential, this commentary reviews the concerns of women living with HIV about human rights, community-based support and other barriers to service uptake and retention in the Option B+ context. Option B+ intensifies many of the pre-existing challenges of HIV prevention and treatment programmes. As women seek comprehensive services to prevent vertical transmission, they can experience various human rights violations, including lack of informed consent, involuntary or coercive HIV testing, limited treatment options, termination of pregnancy or coerced sterilization and pressure to start treatment. Yet, peer and community support strategies can promote treatment readiness, uptake, adherence and lifelong retention in care; reduce stigma and discrimination; and mitigate potential violence stemming from HIV disclosure. Ensuring available and accessible quality care, offering food support and improving linkages to care could increase service uptake and retention. With the heightened focus on interventions to reach pregnant and breastfeeding women living with HIV, a parallel increase in vigilance to secure their health and rights is critical.
The authors conclude that real progress towards reducing vertical transmission and achieving viral load suppression can only be made by upholding the human rights of women living with HIV, investing in community-based responses, and ensuring universal access to quality healthcare. Only then will the opportunity of accessing lifelong treatment result in improving the health, dignity and lives of women living with HIV, their children and families.
2011年,《到2015年消除儿童新发艾滋病毒感染并确保其母亲存活全球计划》启动,旨在加大力度全面终止艾滋病毒垂直传播,并支持感染艾滋病毒的母亲保持健康。在围绕将治疗作为预防手段的热潮中,马拉维卫生部构思了“选项B+”策略,该策略通过让所有感染艾滋病毒的孕妇和哺乳期妇女开始接受终身抗逆转录病毒治疗来预防垂直传播,无论其CD4细胞计数如何。2013年,出于项目和操作方面的原因,世卫组织正式向艾滋病毒广泛流行、难以获得CD4检测、性伴侣检测受限、母乳喂养时间长或生育率高的国家推荐“选项B+”策略。
在承认全球增加治疗机会及其潜力的同时,本评论审视了感染艾滋病毒的妇女在“选项B+”背景下对人权、社区支持以及接受和坚持治疗的其他障碍的担忧。“选项B+”加剧了艾滋病毒预防和治疗项目中许多原有的挑战。当妇女寻求全面服务以预防垂直传播时,她们可能会遭受各种人权侵犯,包括缺乏知情同意、非自愿或强制艾滋病毒检测、治疗选择有限、终止妊娠或强制绝育以及开始治疗的压力。然而,同伴和社区支持策略可以促进治疗准备、接受、坚持和终身接受护理;减少耻辱感和歧视;并减轻因披露艾滋病毒感染状况而可能产生的暴力。确保提供可及的优质护理、提供食物支持并改善护理联系可以增加服务的接受和坚持。随着更加关注针对感染艾滋病毒的孕妇和哺乳期妇女的干预措施,同时提高警惕以保障她们的健康和权利至关重要。
作者得出结论,只有通过维护感染艾滋病毒妇女的人权、投资基于社区的应对措施并确保普遍获得优质医疗保健,才能在减少垂直传播和实现病毒载量抑制方面取得真正进展。只有这样,获得终身治疗的机会才会改善感染艾滋病毒妇女及其子女和家庭的健康、尊严和生活。