去泛素化酶在DNA修复中的作用。
Role of Deubiquitinating Enzymes in DNA Repair.
作者信息
Kee Younghoon, Huang Tony T
机构信息
Department of Cell Biology, Microbiology, and Molecular Biology, College of Arts and Sciences, University of South Florida, Tampa, Florida, USA
Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, USA
出版信息
Mol Cell Biol. 2015 Dec 7;36(4):524-44. doi: 10.1128/MCB.00847-15. Print 2016 Feb 15.
Abstract
Both proteolytic and nonproteolytic functions of ubiquitination are essential regulatory mechanisms for promoting DNA repair and the DNA damage response in mammalian cells. Deubiquitinating enzymes (DUBs) have emerged as key players in the maintenance of genome stability. In this minireview, we discuss the recent findings on human DUBs that participate in genome maintenance, with a focus on the role of DUBs in the modulation of DNA repair and DNA damage signaling.
摘要
泛素化的蛋白水解和非蛋白水解功能都是促进哺乳动物细胞DNA修复和DNA损伤反应的重要调控机制。去泛素化酶（DUBs）已成为维持基因组稳定性的关键因素。在这篇微型综述中，我们讨论了参与基因组维持的人类DUBs的最新研究发现，重点关注DUBs在调节DNA修复和DNA损伤信号传导中的作用。
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