引起尿路感染的大肠杆菌的耐药模式。

Resistance patterns of Escherichia coli causing urinary tract infection.

作者信息

Ferdosi-Shahandashti Elaheh, Javanian Mostafa, Moradian-Kouchaksaraei Masoomeh, Yeganeh Babak, Bijani Ali, Motevaseli Elahe, Moradian-Kouchaksaraei Fatemeh

机构信息

Department of Advanced Technology in Medicine (SATiM), Medical Biotechnology, Tehran University of Medical Sciences, Tehran, Iran.

Infectious Diseases & Tropical Medicine Research Center, Babol University of Medical Sciences, Babol, Iran.

出版信息

Caspian J Intern Med. 2015 Summer;6(3):148-51.

PMID:26644881

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4650789/

Abstract

BACKGROUND

Urinary tract infection (UTI) is one of the most prevalent infectious diseases and Escherichia coli is its common cause. The aim of this study was to assess the resistance patterns of E.coli in urinary tract infections and to determine the susceptibility of E.coli to commonly used antimicrobials and also to evaluate the options for empirical treatment of UTI.

METHODS

This study was conducted in the Ayatollah Rouhani Teaching Hospital of Babol Medical Sciences University in North of Iran. Between January of 2013 to December 2013, antimicrobial susceptibility tests were done by disk diffusion and microdilution method. Growth of >=10(5) cfu/ml was considered as positive urine test. Ten commonly used antibiotics were examined for susceptibility test. Data and the results were collected and analyzed.

RESULTS

E.coli grew in 57 urine samples. Imipenem, ofloxacin, ciprofloxacin were the most sensitive antibiotics at 87.7%, 87.7% and 78.9% respectively. Whereas, cotrimoxazole, cefexime, cefotaxcime and ceftriaxone were the most resistant antibiotics. Antibiotic sensitivity of disk diffusion compared minimum inhibitory concentration (MIC) detected by microdilution had the sensitivity, specificity, positive predictive value and negative predictive value of 82%, 98%, 99% and 74%, respectively.

CONCLUSION

Imipenem, ofloxacin and ciprofloxacin should be used in empirical therapy of UTI.

摘要

背景

尿路感染（UTI）是最常见的传染病之一，大肠杆菌是其常见病因。本研究的目的是评估尿路感染中大肠杆菌的耐药模式，确定大肠杆菌对常用抗菌药物的敏感性，并评估尿路感染经验性治疗的选择。

方法

本研究在伊朗北部巴博勒医科大学的阿亚图拉·鲁哈尼教学医院进行。2013年1月至2013年12月期间，采用纸片扩散法和微量稀释法进行抗菌药物敏感性试验。尿培养菌落计数≥10(5) cfu/ml被视为尿检阳性。对十种常用抗生素进行敏感性试验。收集并分析数据及结果。

结果

57份尿样中培养出大肠杆菌。亚胺培南、氧氟沙星、环丙沙星是最敏感的抗生素，敏感性分别为87.7%、87.7%和78.9%。而复方新诺明、头孢克肟、头孢噻肟和头孢曲松是耐药性最强的抗生素。纸片扩散法检测的抗生素敏感性与微量稀释法检测的最低抑菌浓度（MIC）相比，其敏感性、特异性、阳性预测值和阴性预测值分别为82%、98%、99%和74%。