朊病毒蛋白瘙痒病与正常细胞朊病毒蛋白。
Prion protein scrapie and the normal cellular prion protein.
作者信息
Atkinson Caroline J, Zhang Kai, Munn Alan L, Wiegmans Adrian, Wei Ming Q
机构信息
a Division of Molecular and Gene Therapies, Menzies Health Institute, Griffith University , Gold Coast , QLD , Australia.
b Laboratory of Yeast Cell Biology, Molecular Basis of Disease Program, Menzies Health Institute Queensland and School of Medical Science, Griffith University , Gold Coast , QLD , Australia.
出版信息
Prion. 2016;10(1):63-82. doi: 10.1080/19336896.2015.1110293.
Prions are infectious proteins and over the past few decades, some prions have become renowned for their causative role in several neurodegenerative diseases in animals and humans. Since their discovery, the mechanisms and mode of transmission and molecular structure of prions have begun to be established. There is, however, still much to be elucidated about prion diseases, including the development of potential therapeutic strategies for treatment. The significance of prion disease is discussed here, including the categories of human and animal prion diseases, disease transmission, disease progression and the development of symptoms and potential future strategies for treatment. Furthermore, the structure and function of the normal cellular prion protein (PrP(C)) and its importance in not only in prion disease development, but also in diseases such as cancer and Alzheimer's disease will also be discussed.
朊病毒是传染性蛋白质，在过去几十年里，一些朊病毒因其在动物和人类的几种神经退行性疾病中的致病作用而声名远扬。自发现以来，朊病毒的传播机制、传播方式和分子结构已开始得到确立。然而，关于朊病毒疾病仍有许多有待阐明的地方，包括潜在治疗策略的开发。本文讨论了朊病毒疾病的重要性，包括人类和动物朊病毒疾病的类别、疾病传播、疾病进展、症状发展以及未来潜在的治疗策略。此外，还将讨论正常细胞朊病毒蛋白（PrP(C)）的结构和功能，以及它不仅在朊病毒疾病发展中，而且在癌症和阿尔茨海默病等疾病中的重要性。
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