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大脑大静脉动脉瘤:与该畸形发病机制相关的胚胎学考量及解剖学特征

Aneurysms of the vein of Galen: embryonic considerations and anatomical features relating to the pathogenesis of the malformation.

作者信息

Raybaud C A, Strother C M, Hald J K

机构信息

Hopital Nord, Marseille, France.

出版信息

Neuroradiology. 1989;31(2):109-28. doi: 10.1007/BF00698838.

DOI:10.1007/BF00698838
PMID:2664553
Abstract

Vein of Galen aneurysms may be defined as direct arteriovenous fistulas between choroidal and/or quadrigeminal arteries and an overlying single median venous sac. Anatomic analysis of 23 cases of vein of Galen aneurysm and correlation with known embryologic data indicate that the venous sac most probably represents persistence of the embryonic median prosencephalic vein of Markowski, not the vein of Galen, per se. The frequent concurrent venous abnormalities are easily understood as (a) retention of fetal anatomical features and (b) frequent occlusions of the dural sinuses of the posterior fossa, especially the sigmoid sinuses.

摘要

大脑大静脉动脉瘤可定义为脉络膜动脉和/或四叠体动脉与上方单一的正中静脉囊之间的直接动静脉瘘。对23例大脑大静脉动脉瘤的解剖分析及其与已知胚胎学数据的相关性表明,静脉囊很可能代表马尔科夫斯基胚胎前脑正中静脉的残留,而非大脑大静脉本身。常见的并发静脉异常很容易理解为:(a)胎儿解剖特征的保留;(b)后颅窝硬脑膜窦,尤其是乙状窦的频繁闭塞。

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1
Aneurysms of the vein of Galen: embryonic considerations and anatomical features relating to the pathogenesis of the malformation.大脑大静脉动脉瘤:与该畸形发病机制相关的胚胎学考量及解剖学特征
Neuroradiology. 1989;31(2):109-28. doi: 10.1007/BF00698838.
2
[Aneurysms of the vein of Galen. Angiographic study and morphogenetic considerations].[大脑大静脉动脉瘤。血管造影研究及形态发生学考量]
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Persisting abnormal embryonic vessels in intracranial arteriovenous malformations.颅内动静脉畸形中持续存在的异常胚胎血管。
Acta Radiol Suppl. 1986;369:136-8.
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Spontaneously healed vein of Galen aneurysms. Clinical radiological features.自发性治愈的大脑大静脉动脉瘤。临床放射学特征。
Childs Nerv Syst. 1991 Jun;7(3):129-34. doi: 10.1007/BF00776707.
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Confirmation of communication between deep venous drainage and the vein of galen after treatment of a vein of Galen aneurysmal malformation in an infant presenting with severe pulmonary hypertension.一名患有严重肺动脉高压的婴儿在接受大脑大静脉动脉瘤样畸形治疗后,对其深静脉引流与大脑大静脉之间的交通进行确认。
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Normal galenic drainage of the deep cerebral venous system in two cases of vein of Galen aneurysmal malformation.两例大脑大静脉动脉瘤样畸形患者大脑深部静脉系统的正常盖伦氏引流。
Childs Nerv Syst. 2004 Feb;20(2):91-7; discussion 98-9. doi: 10.1007/s00381-003-0841-y. Epub 2003 Dec 23.
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Angiographic analysis and results of endovascular therapy of aneurysm of vein of Galen.大脑大静脉瘤的血管造影分析及血管内治疗结果
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Pial Arteriovenous Fistula with Multiple Venous Aneurysms Resembling a Vein of Galen Aneurysmal Malformation; Case Report and Review of Literature.硬脑膜动静脉瘘伴多发静脉瘤,类似静脉型 Galien 动脉瘤样畸形;病例报告及文献复习。
World Neurosurg. 2019 Jul;127:245-248. doi: 10.1016/j.wneu.2019.04.061. Epub 2019 Apr 11.
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[Embryology of the cerebral veins].[脑静脉的胚胎学]
Neurochirurgie. 1987;33(4):258-63.
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Intracranial venous aneurysms: vein of Galen and other similar vascular anomalies.颅内静脉动脉瘤:大脑大静脉及其他类似血管异常
J Comput Tomogr. 1983 Nov;7(4):345-50. doi: 10.1016/0149-936x(83)90056-5.

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In Utero Embolization for Fetal Vein of Galen Malformation.胎儿大脑大静脉畸形的宫内栓塞治疗
JAMA. 2025 Aug 11. doi: 10.1001/jama.2025.12363.
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Arteriovenous cerebral high-flow shunts: genetic analysis of patients from a pediatric tertiary care center.脑动静脉高流量分流术:来自一家儿科三级护理中心患者的基因分析
Front Genet. 2025 Mar 28;16:1430657. doi: 10.3389/fgene.2025.1430657. eCollection 2025.
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Cerebral transmantle vein on magnetic resonance imaging: an embryological pattern persisting up to the adulthood.磁共振成像上的大脑跨髓静脉:一种持续至成年期的胚胎学模式。

本文引用的文献

1
Arteriovenous aneurysm of great cerebral vein and arteries of circle of Willis; formation by junction of the great cerebral vein and the straight sinus and by the choroidal arteries and anomalous branches of the posterior cerebral arteries.大脑大静脉及 Willis 环动脉的动静脉瘤;由大脑大静脉与直窦的连接处以及脉络膜动脉和大脑后动脉的异常分支形成。
Arch Neurol Psychiatry. 1945 Sep;54:181-5. doi: 10.1001/archneurpsyc.1945.02300090020003.
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Bilateral congenital arteriovenous communications (aneurysm) of the cerebral vessels.双侧先天性脑血管动静脉交通(动脉瘤)
Arch Neurol Psychiatry. 1946 Jun;55:591-9. doi: 10.1001/archneurpsyc.1946.02300170035005.
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Surg Radiol Anat. 2025 Apr 21;47(1):124. doi: 10.1007/s00276-025-03638-4.
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Vein of Galen Aneurysmal Malformations: Updates on Technical Aspects and Functional Outcomes Post-Endovascular Treatment-A Systematic Review and Meta-Analysis.大脑大静脉动脉瘤样畸形:血管内治疗后技术方面及功能预后的最新进展——一项系统评价与荟萃分析
Medicina (Kaunas). 2024 Nov 26;60(12):1948. doi: 10.3390/medicina60121948.
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Adjunctive venous sinus stenting in transvenous embolization of vein of Galen malformations.在大脑大静脉畸形经静脉栓塞中辅助性静脉窦支架置入术
Interv Neuroradiol. 2024 Oct 3:15910199241282719. doi: 10.1177/15910199241282719.
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Vein of galen malformations: for patients and caregivers.Galen 静脉畸形:患者和护理人员须知。
Neurosurg Rev. 2024 Sep 11;47(1):587. doi: 10.1007/s10143-024-02851-w.
7
A Case of Vein of Galen Aneurysmal Malformation Diagnosed Prenatally in a Monochorionic-Diamniotic Twin Pregnancy.一例在单绒毛膜双羊膜囊双胎妊娠中产前诊断的大脑大静脉动脉瘤样畸形病例。
AJP Rep. 2024 Aug 29;14(3):e202-e204. doi: 10.1055/a-2385-1263. eCollection 2024 Jul.
8
Pediatric interventional neuroradiology: "How I do it" vol. II-Embolization.小儿介入神经放射学:“我的操作方法”第二卷——栓塞术
Interv Neuroradiol. 2024 Aug 25:15910199241275710. doi: 10.1177/15910199241275710.
9
Cerebrovascular Anomalies in the Fetus.胎儿脑血管异常
AJNR Am J Neuroradiol. 2025 Feb 3;46(2):231-239. doi: 10.3174/ajnr.A8377.
10
Neonatal intracranial haemorrhage secondary to vein of Galen aneurysmal dilatation.继发于 Galen 静脉动脉瘤样扩张的新生儿颅内出血。
Childs Nerv Syst. 2024 Sep;40(9):2973-2976. doi: 10.1007/s00381-024-06481-x. Epub 2024 Jun 10.
A Vascular Mechanism related to the Great Vein of Galen.
一种与大脑大静脉相关的血管机制。
Br Med J. 1940 Mar 23;1(4133):476. doi: 10.1136/bmj.1.4133.476.
4
A case of aneurysm of the vein of Galen.一例大脑大静脉动脉瘤病例。
J Pathol Bacteriol. 1947 Jan-Apr;59(1-2):328-31. doi: 10.1002/path.1700590139.
5
Arteriovenous fistula (aneurysm) of the great cerebral vein (of Galen) and the circle of Willis; report on two patients treated by ligation.大脑大静脉(Galen静脉)和Willis环的动静脉瘘(动脉瘤);两例结扎治疗患者的报告
Arch Neurol Psychiatry. 1949 Dec;62(6):778-83, illust. doi: 10.1001/archneurpsyc.1949.02310180079009.
6
The transcerebral venous system. An anatomical study.经脑静脉系统。一项解剖学研究。
Arch Neurol. 1959 Aug;1:148-52. doi: 10.1001/archneur.1959.03840020022004.
7
The development of the paraphysis cerebri in man with comments on its relationship to the intercolumnar tubercle and its significance for the origin of cystic tumors in the third ventricle.人脑脉络丛旁突体的发育及其与柱间结节的关系和对第三脑室囊性肿瘤起源的意义述评
J Comp Neurol. 1955 Apr;102(2):425-509. doi: 10.1002/cne.901020205.
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ANEURYSM OF THE VEIN OF GALEN: CASE REPORT AND REVIEW OF THE LITERATURE.大脑大静脉动脉瘤:病例报告及文献综述
Am J Roentgenol Radium Ther Nucl Med. 1964 Oct;92:756-60.
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VEIN OF GALEN MALFORMATION.大脑大静脉畸形
Acta Neurol Scand Suppl. 1964;40:SUPPL 11:1-31.
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Aneurysm of the vein of Galen.大脑大静脉动脉瘤
Br J Radiol. 1959 Oct;32:680-4. doi: 10.1259/0007-1285-32-382-680.