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Effects of combination treatment with sirolimus and mitotane on growth of human adrenocortical carcinoma cells.

作者信息

De Martino Maria Cristina, van Koetsveld Peter M, Feelders Richard A, Lamberts Steven W J, de Herder Wouter W, Colao Annamaria, Pivonello Rosario, Hofland Leo J

机构信息

Division of Endocrinology, Department of Internal Medicine, Erasmus MC, Dr. Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands.

Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Uniniversità Federico II di Napoli, Via S. Pansini 5, 80131, Naples, Italy.

出版信息

Endocrine. 2016 Jun;52(3):664-7. doi: 10.1007/s12020-015-0818-0. Epub 2015 Dec 8.

DOI:10.1007/s12020-015-0818-0
PMID:26645813
Abstract
摘要

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3
Adjuvant mitotane in adrenocortical carcinoma.肾上腺皮质癌的辅助性米托坦治疗
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4
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Lipoprotein-Free Mitotane Exerts High Cytotoxic Activity in Adrenocortical Carcinoma.无脂蛋白米托坦在肾上腺皮质癌中具有高细胞毒性活性。
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CYP11B1 has no role in mitotane action and metabolism in adrenocortical carcinoma cells.CYP11B1 在人肾上腺皮质癌细胞中不参与米托坦的作用及其代谢。
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The effects of mitotane and 1α,25-dihydroxyvitamin D on Wnt/beta-catenin signaling in human adrenocortical carcinoma cells.米托坦和 1α,25-二羟维生素 D 对人肾上腺皮质癌细胞中 Wnt/β-连环蛋白信号通路的影响。
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The role of mTOR pathway as target for treatment in adrenocortical cancer.

本文引用的文献

1
Characterization of the mTOR pathway in human normal adrenal and adrenocortical tumors.人正常肾上腺及肾上腺皮质肿瘤中mTOR信号通路的特征分析
Endocr Relat Cancer. 2014 Aug;21(4):601-13. doi: 10.1530/ERC-13-0112. Epub 2014 Jun 2.
2
Molecular screening for a personalized treatment approach in advanced adrenocortical cancer.晚期肾上腺皮质癌的个体化治疗方法的分子筛选。
J Clin Endocrinol Metab. 2013 Oct;98(10):4080-8. doi: 10.1210/jc.2013-2165. Epub 2013 Aug 26.
3
Interferon-β is a potent inhibitor of cell growth and cortisol production in vitro and sensitizes human adrenocortical carcinoma cells to mitotane.
mTOR通路在肾上腺皮质癌治疗中作为靶点的作用。
Endocr Connect. 2019 Sep;8(9):R144-R156. doi: 10.1530/EC-19-0224.
4
Targeting PDZ-binding kinase is anti-tumorigenic in novel preclinical models of ACC.针对 PDZ 结合激酶的治疗在 ACC 的新型临床前模型中具有抗肿瘤作用。
Endocr Relat Cancer. 2019 Oct;26(10):765-778. doi: 10.1530/ERC-19-0262.
5
Tissue Expression and Pharmacological In Vitro Analyses of mTOR and SSTR Pathways in Adrenocortical Carcinoma.肾上腺皮质癌中mTOR和SSTR通路的组织表达及药理学体外分析
Endocr Pathol. 2017 Jun;28(2):95-102. doi: 10.1007/s12022-017-9473-8.
6
Palbociclib inhibits proliferation of human adrenocortical tumor cells.帕博西尼抑制人肾上腺皮质肿瘤细胞的增殖。
Endocrine. 2018 Jan;59(1):213-217. doi: 10.1007/s12020-017-1270-0. Epub 2017 Mar 6.
干扰素-β 在体外是一种有效的细胞生长和皮质醇产生抑制剂，并使人类肾上腺皮质癌细胞对米托坦敏感。
Endocr Relat Cancer. 2013 May 30;20(3):443-54. doi: 10.1530/ERC-12-0217. Print 2013 Jun.
4
Everolimus therapy for progressive adrenocortical cancer.依维莫司治疗进展性肾上腺皮质癌。
Endocrine. 2013 Aug;44(1):187-92. doi: 10.1007/s12020-013-9878-1. Epub 2013 Feb 16.
5
Insulin growth factor receptor (IGF-1R) antibody cixutumumab combined with the mTOR inhibitor temsirolimus in patients with metastatic adrenocortical carcinoma.胰岛素样生长因子受体（IGF-1R）抗体西妥昔单抗联合 mTOR 抑制剂替西罗莫司治疗转移性肾上腺皮质癌患者。
Br J Cancer. 2013 Mar 5;108(4):826-30. doi: 10.1038/bjc.2013.46. Epub 2013 Feb 14.
6
Adrenal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.肾上腺癌：ESMO 诊断、治疗及随访临床实践指南
Ann Oncol. 2012 Oct;23 Suppl 7:vii131-8. doi: 10.1093/annonc/mds231.
7
Combination chemotherapy in advanced adrenocortical carcinoma.晚期肾上腺皮质癌的联合化疗。
N Engl J Med. 2012 Jun 7;366(23):2189-97. doi: 10.1056/NEJMoa1200966. Epub 2012 May 2.
8
The role of mTOR inhibitors in the inhibition of growth and cortisol secretion in human adrenocortical carcinoma cells.mTOR 抑制剂在抑制人肾上腺皮质癌细胞生长和皮质醇分泌中的作用。
Endocr Relat Cancer. 2012 May 24;19(3):351-64. doi: 10.1530/ERC-11-0270. Print 2012 Jun.
9
Therapeutic management of advanced adrenocortical carcinoma: what do we know in 2011?2011 年晚期肾上腺皮质癌的治疗管理：我们了解多少？
Horm Cancer. 2011 Dec;2(6):363-71. doi: 10.1007/s12672-011-0094-2.
10
Human adrenocortical carcinoma cell lines.人肾上腺皮质癌细胞系。
Mol Cell Endocrinol. 2012 Mar 31;351(1):58-65. doi: 10.1016/j.mce.2011.08.041. Epub 2011 Sep 5.