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肾脏研究方法:大鼠肾移植

Methods in renal research: kidney transplantation in the rat.

作者信息

Tillou Xavier, Howden Brian O, Kanellis John, Nikolic-Paterson David J, Ma Frank Y

机构信息

Department of Nephrology, Monash Health and Department of Medicine, Southern Clinical School, Monash University, Monash Medical Centre, Melbourne, Victoria, Australia.

Unicaen, Caen, France.

出版信息

Nephrology (Carlton). 2016 Jun;21(6):451-6. doi: 10.1111/nep.12697.

Abstract

Kidney transplantation in small animals has been crucial in the development of anti-rejection therapies. While there is no substitute for a skilled microsurgeon, there are many aspects of the transplant procedure that can be modified to optimize the reproducibility and utility of the technique. This article provides a detailed description, including video recording, of orthotopic kidney transplantation in the rat. The key variables in the technique are also discussed.

摘要

小动物肾移植在抗排斥疗法的发展中至关重要。虽然熟练的显微外科医生无可替代,但移植手术的许多方面可以进行改进,以优化该技术的可重复性和实用性。本文详细描述了大鼠原位肾移植,包括视频记录。还讨论了该技术的关键变量。

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