Noel Sanjeev, Hamad Abdel R A, Rabb Hamid
Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
Kidney Int. 2015 Dec;88(6):1217-1218. doi: 10.1038/ki.2015.328.
The transcription factor Nrf2 plays an important role in many kidney diseases from acute kidney injury to chronic kidney disease, and there have been preliminary Nrf2-based therapeutic trials in humans. Shelton et al. presents an integrated transcriptomic and proteomic analysis of mouse kidney to reveal Nrf2 targets with potentially important roles in kidney homeostasis and pathophysiology. These results can further our understanding of Nrf2-based mechanisms and help in the development of therapeutics for a wide range of kidney diseases.
转录因子Nrf2在从急性肾损伤到慢性肾病的许多肾脏疾病中发挥着重要作用，并且已经有了基于Nrf2的人体治疗试验。谢尔顿等人对小鼠肾脏进行了综合转录组学和蛋白质组学分析，以揭示在肾脏内环境稳定和病理生理学中具有潜在重要作用的Nrf2靶点。这些结果可以加深我们对基于Nrf2的机制的理解，并有助于开发针对多种肾脏疾病的治疗方法。
