Perry Heather M, Okusa Mark D
Division of Nephrology and Center for Immunity, Inflammation and Regenerative Medicine, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA.
Kidney Int. 2015 Dec;88(6):1219-1221. doi: 10.1038/ki.2015.324.
Macrophage colony-stimulating factor (CSF-1 or M-CSF) is important for kidney repair after acute kidney injury (AKI). CSF-1 is upregulated in tubule epithelial cells in response to kidney injury stimuli and binds to its sole receptor, CSF1R, in an autocrine and paracrine manner. Wang and colleagues used a genetic approach to constitutively delete Csf1 in proximal tubules to establish that proximal tubule production of CSF-1 is important for polarizing and skewing macrophages toward an M2 phenotype, and for recovery from AKI.
巨噬细胞集落刺激因子(CSF-1 或 M-CSF)对急性肾损伤(AKI)后的肾脏修复很重要。CSF-1 在肾小管上皮细胞中因肾损伤刺激而上调,并以自分泌和旁分泌方式与其唯一受体 CSF1R 结合。Wang 及其同事采用基因方法在近端小管中组成性删除 Csf1,以确定近端小管产生的 CSF-1 对于使巨噬细胞极化并偏向 M2 表型以及从 AKI 中恢复很重要。