Georgescu C
N. Gh. Lupu, Institute of Internal Medicine, Bucharest, Romania.
Med Interne. 1989 Jan-Mar;27(1):53-6.
Cyclosporin A (CyA) was administered in 6 cases of classical or definite, seropositive rheumatoid arthritis (RA), stages II or III, resistant to the antiinflammatory or nonsteroid therapy, or dependent on high Prednisone doses. An intramuscular daily dose of 1.5 g CyA for a three-week period had good clinical and biologic results. The first signs of improvement, occurring after 14 days of therapy, were manifested by a reduction of the articular inflammation, increase in amplitude of the articular mobility, decrease of the morning stiffness and lowering of the ESR rate. The short-term application of this treatment permits the reintroduction of the nonsteroid drugs and a lowering of the daily dose of Prednisone.
对6例处于II或III期、对抗炎或非甾体治疗耐药或依赖高剂量泼尼松的典型或确诊的血清阳性类风湿性关节炎（RA）患者给予环孢素A（CyA）。每日肌肉注射1.5g CyA，持续三周，取得了良好的临床和生物学效果。治疗14天后出现的首个改善迹象表现为关节炎症减轻、关节活动幅度增加、晨僵减轻以及血沉降低。这种治疗的短期应用允许重新使用非甾体药物并降低泼尼松的每日剂量。
