Jepsen S, Nielsen P H, Klaerke A, Nielsen S T, Simonsen O
Department of Thoracic and Vascular Surgery, Aalborg Sygehus, Denmark.
Scand J Thorac Cardiovasc Surg. 1989;23(2):185-8. doi: 10.3109/14017438909105992.
In a randomized, double-blind study, 38 patients undergoing elective pulmonary surgery were given N-acetylcysteine (Fabrol, Ciba-Geigy) in recommended dosage (200 mg X 3) or placebo. The prophylactic effect on postoperative bronchopulmonary complications was evaluated from arterial blood-gas analyses and chest radiography. The alveolo-arterial oxygen difference increased substantially and similarly in both patient groups, and no intergroup difference was found in incidence of atelectasis or pneumonic infiltration. Thus there was no demonstrable benefit of N-acetylcysteine in the recommended dosage. For future similar studies, employment of considerably higher doses is proposed.
在一项随机双盲研究中，38例接受择期肺手术的患者被给予推荐剂量（200毫克×3）的N-乙酰半胱氨酸（法布罗尔，汽巴-嘉基公司）或安慰剂。通过动脉血气分析和胸部X线检查评估对术后支气管肺并发症的预防效果。两组患者的肺泡-动脉氧分压差均显著且相似地增加，在肺不张或肺炎性浸润的发生率方面未发现组间差异。因此，推荐剂量的N-乙酰半胱氨酸没有明显益处。对于未来类似的研究，建议使用相当高的剂量。
