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1
3,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors.
Medchemcomm. 2014 Dec;5(12):1863-1870. doi: 10.1039/C4MD00283K.
2
Reversible inhibitors of LSD1 as therapeutic agents in acute myeloid leukemia: clinical significance and progress to date.
Med Res Rev. 2015 May;35(3):586-618. doi: 10.1002/med.21334. Epub 2014 Nov 24.
3
Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer.
Oncotarget. 2014 Nov 15;5(21):10665-77. doi: 10.18632/oncotarget.2496.
4
Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity.
J Med Chem. 2014 Oct 23;57(20):8307-18. doi: 10.1021/jm500660f. Epub 2014 Oct 1.
5
Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders.
Nat Rev Drug Discov. 2014 Sep;13(9):673-91. doi: 10.1038/nrd4360. Epub 2014 Aug 18.
6
DOT1L inhibition sensitizes MLL-rearranged AML to chemotherapy.
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7
A selective phenelzine analogue inhibitor of histone demethylase LSD1.
ACS Chem Biol. 2014 Jun 20;9(6):1284-93. doi: 10.1021/cb500018s. Epub 2014 Apr 7.
8
High-throughput virtual screening identifies novel N'-(1-phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors.
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9
Triazole-dithiocarbamate based selective lysine specific demethylase 1 (LSD1) inactivators inhibit gastric cancer cell growth, invasion, and migration.
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10
Potent inhibition of DOT1L as treatment of MLL-fusion leukemia.
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