Yachi A, Tsujisaki M, Imai K
Dept. of Internal Medicine, Sapporo Medical College.
Gan To Kagaku Ryoho. 1989 Jul;16(7):2313-20.
The concept of idiotype networks are supposed to play important roles in regulation of the immune response, and anti-idiotypic (anti-Id) antibodies have enabled to analyze the pathogenesis of autoimmune diseases and structural relations of receptors and ligands in clinical fields. We applied anti-idiotypic monoclonal antibodies (MoAb) to tumor immunology to analyze idiotype network system of tumor associated antigen (TAA) and to investigate the fine structure of TAAs and their corresponding antibodies. New assays were established to detect circulating TAAs, anti-TAA antibodies and their immune complex regarding YH 206 antigen and carcinoembryonic antigen (CEA) systems. The measurement of anti-TAA antibodies and immune complex was found to be of value for the cancer diagnosis. The results about immune response with use of anti-Id monoclonal antibodies suggest that some of the anti-Id antibodies might be useful for cancer therapy, since anti-Id antibody could induce anti-anti-Id antibodies reactive with tumor antigen. In this review, the usefulness of anti-Id MoAb to serodiagnosis and immunotherapy for cancer was discussed.
独特型网络的概念被认为在免疫反应调节中发挥重要作用，抗独特型（抗Id）抗体已能够在临床领域分析自身免疫性疾病的发病机制以及受体与配体的结构关系。我们将抗独特型单克隆抗体（MoAb）应用于肿瘤免疫学，以分析肿瘤相关抗原（TAA）的独特型网络系统，并研究TAA及其相应抗体的精细结构。针对YH 206抗原和癌胚抗原（CEA）系统，建立了新的检测循环TAA、抗TAA抗体及其免疫复合物的方法。发现抗TAA抗体和免疫复合物的检测对癌症诊断具有价值。使用抗Id单克隆抗体的免疫反应结果表明，一些抗Id抗体可能对癌症治疗有用，因为抗Id抗体可诱导与肿瘤抗原反应的抗抗Id抗体。在本综述中，讨论了抗Id MoAb对癌症血清学诊断和免疫治疗的实用性。
