在加泰罗尼亚地区，接种率较低，13价肺炎球菌结合疫苗接种规范的患者中出现疫苗接种失败情况。
Vaccine Failures in Patients Properly Vaccinated with 13-Valent Pneumococcal Conjugate Vaccine in Catalonia, a Region with Low Vaccination Coverage.
作者信息
Moraga-Llop Fernando, Garcia-Garcia Juan-Jose, Díaz-Conradi Alvaro, Ciruela Pilar, Martínez-Osorio Johanna, González-Peris Sebastià, Hernández Sergi, de Sevilla Mariona Fernández, Uriona Sonia, Izquierdo Conchita, Selva Laura, Campins Magda, Codina Gemma, Batalla Joan, Esteva Cristina, Domínguez Àngela, Muñoz-Almagro Carmen
机构信息
From the *Pediatrics, Hospital Vall d'Hebron, Barcelona, Spain; †Pediatrics, Hospital Sant Joan de Déu, Barcelona, Spain; ‡Pediatrics, Hospital de Nens, Barcelona, Spain; §Departament de Salut, Agència de Salut Pública de Catalunya, Barcelona, Spain; ¶Microbiology, Hospital Vall d'Hebron, Barcelona, Spain; ‖Preventive Medicine, Hospital Vall d'Hebron, Barcelona, Spain; **CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; ††Molecular Microbiology, Hospital Sant Joan de Déu, Barcelona, Spain; and ‡‡ Departament de Salut Pública, Universitat de Barcelona, Barcelona, Spain.
出版信息
Pediatr Infect Dis J. 2016 Apr;35(4):460-3. doi: 10.1097/INF.0000000000001041.
Vaccine failures occurring with 13-valent pneumococcal conjugate vaccine (PCV13) in 3 pediatric hospitals in Barcelona (2012-2013) are described. PCV13 vaccine failure was defined as the occurrence of an invasive pneumococcal infection in children properly vaccinated by PCV13. Among 84 patients with invasive pneumococcal infection, 32 had received at least one dose of PCV13. Seventeen of them had invasive pneumococcal infection produced by a PCV13 serotype. Among those, 9 patients were considered to have a PCV13 vaccine failure. Serotype 3 was isolated in 6 patients, serotype 19A in 2 and serotype 6B in 1.
描述了2012 - 2013年巴塞罗那3家儿科医院中13价肺炎球菌结合疫苗（PCV13）出现的疫苗接种失败情况。PCV13疫苗接种失败定义为接种PCV13疫苗的儿童发生侵袭性肺炎球菌感染。在84例侵袭性肺炎球菌感染患者中，32例至少接种过一剂PCV13。其中17例感染由PCV13血清型引起。在这些患者中，9例被认为发生了PCV13疫苗接种失败。6例患者分离出3型，2例为19A型，1例为6B型。
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