Ngendahayo P, Mets T, Bugingo G, Parkin D M
Service d'Anatomie Pathologique, Faculté de Médecine, Butare, Rwanda.
Bull Cancer. 1989;76(4):383-94.
The clinico-pathological and epidemiological features of 119 cases of Kaposi's sarcoma diagnosed during the years 1979-1986 in the main pathology department of Rwanda are presented. Skin involvement (89%) was predominant with almost 70% of cutaneous lesions localised on the lower limbs; 11% of cases presented with extracutaneous localisations, 77% (10 cases out of 13) in the lymph nodes. Incidence rises progressively with age, and males are more affected than females with a sex ratio (m:f) of 6.4:1. The highest frequencies were observed in the western prefectures which border the province of Kivu in eastern Zaire. Histologically, three types were encountered: a mixed type (84%), a spindle cell-predominant type (12.6%) and an anaplastic type (3.4%). The factor VIII-related antigen was present in all 40 cases tested by the PAP method. Antihuman immunodeficiency virus antibodies were looked for in 18 cases: 10 cases with localised Kaposi's sarcoma, all of whom were seronegative, and 8 cases with aggressive generalised Kaposi's sarcoma, all of whom were seropositive. The results are compared with those of other authors, and the histogenesis and pathogenesis, particularly the relationship with the acquired immunodeficiency syndrome, are discussed.
本文介绍了1979年至1986年期间在卢旺达主要病理科诊断的119例卡波西肉瘤的临床病理和流行病学特征。皮肤受累（89%）占主导，近70%的皮肤病变位于下肢；11%的病例出现皮肤外定位，77%（13例中的10例）位于淋巴结。发病率随年龄逐渐上升，男性比女性更易受累，男女比例为6.4:1。在与扎伊尔东部基伍省接壤的西部省份观察到最高发病率。组织学上，有三种类型：混合型（84%）、梭形细胞为主型（12.6%）和间变性型（3.4%）。通过PAP法检测的所有40例病例中均存在VIII因子相关抗原。对18例患者进行了抗人类免疫缺陷病毒抗体检测：10例局限性卡波西肉瘤患者，均为血清阴性；8例侵袭性播散性卡波西肉瘤患者，均为血清阳性。将结果与其他作者的结果进行了比较，并讨论了组织发生和发病机制，特别是与获得性免疫缺陷综合征的关系。
