Huntley A C
University of California, Davis.
Dermatol Clin. 1989 Jul;7(3):531-46.
Diabetes mellitus is a common condition, and persons who have this ailment are commonly encountered by dermatologists and primary care physicians. Because glucose attaches to long-lived proteins, it may have a profound effect on the tertiary structure of the protein. Chronic hyperglycemia may be responsible for the pathogenesis of many diabetic complications. It has been suggested that increased cross-linking of collagen in diabetic patients is responsible for the fact that their skin is generally thicker than that of nondiabetics. Advanced glycosylation end-products are probably responsible for yellowing of skin and nails. Increased viscosity of blood caused by stiff red blood cell membranes results in engorgement of the postcapillary venules in the papillary dermis, which is detected as erythema of the face or as periungual erythema. It is suggested that these skin changes may eventually be used as a reflection of the patient's current (as well as past) metabolic status.
糖尿病是一种常见病症，皮肤科医生和初级保健医生经常会遇到患有这种疾病的人。由于葡萄糖会附着在长寿蛋白质上，它可能会对蛋白质的三级结构产生深远影响。慢性高血糖可能是许多糖尿病并发症发病机制的原因。有人提出，糖尿病患者胶原蛋白交联增加是其皮肤通常比非糖尿病患者厚的原因。晚期糖基化终产物可能是皮肤和指甲变黄的原因。僵硬的红细胞膜导致血液粘度增加，致使乳头真皮层毛细血管后微静脉充血，表现为面部红斑或甲周红斑。有人认为，这些皮肤变化最终可能会被用作反映患者当前（以及过去）代谢状态的指标。
