mdx小鼠的肌肉损伤、代谢与氧化应激：有氧运动的影响
Muscle damage, metabolism, and oxidative stress in mdx mice: Impact of aerobic running.
作者信息
Schill Kevin E, Altenberger Alex R, Lowe Jeovanna, Periasamy Muthu, Villamena Frederick A, Rafael-Fortney JIll A, Devor Steven T
机构信息
Department of Human Sciences, Kinesiology Program, The Ohio State University, Columbus, Ohio, USA.
Department of Molecular & Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
出版信息
Muscle Nerve. 2016 Jun;54(1):110-7. doi: 10.1002/mus.25015.
INTRODUCTION
We tested how a treadmill exercise program influences oxygen consumption, oxidative stress, and exercise capacity in the mdx mouse, a model of Duchenne muscular dystrophy.
METHODS
At age 4 weeks mdx mice were subjected to 4 weeks of twice-weekly treadmill exercise. Sedentary mdx and wild-type mice served as controls. Oxygen consumption, time to exhaustion, oxidative stress, and myofiber damage were assessed.
RESULTS
At age 4 weeks, there was a significant difference in exercise capacity between mdx and wild-type mice. After exercise, mdx mice had lower basal oxygen consumption and exercise capacity, but similar maximal oxygen consumption. Skeletal muscle from these mice displayed increased oxidative stress. Collagen deposition was higher in exercised versus sedentary mice.
CONCLUSIONS
Exercised mdx mice exhibit increased oxidative stress, as well as deficits in exercise capacity, baseline oxygen consumption, and increased myofiber fibrosis. Muscle Nerve 54: 110-117, 2016.
引言
我们测试了跑步机运动计划如何影响杜氏肌营养不良症模型mdx小鼠的耗氧量、氧化应激和运动能力。
方法
4周龄的mdx小鼠接受为期4周的每周两次跑步机运动。久坐不动的mdx小鼠和野生型小鼠作为对照。评估了耗氧量、力竭时间、氧化应激和肌纤维损伤。
结果
4周龄时，mdx小鼠和野生型小鼠的运动能力存在显著差异。运动后，mdx小鼠的基础耗氧量和运动能力较低，但最大耗氧量相似。这些小鼠的骨骼肌显示氧化应激增加。与久坐不动的小鼠相比，运动小鼠的胶原蛋白沉积更高。
结论
运动的mdx小鼠表现出氧化应激增加，以及运动能力、基线耗氧量不足和肌纤维纤维化增加。《肌肉与神经》54: 110 - 117, 2016年。
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