Research Group on Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences University of South Santa Catarina, Palhoça, SC, Brazil.
CEU Cardenal Herrera University, Valencia, Spain.
J Mol Neurosci. 2020 Oct;70(10):1552-1564. doi: 10.1007/s12031-020-01565-0. Epub 2020 Jun 8.
Duchenne muscular dystrophy (DMD) is a condition caused by an amendment to the X chromosome, inherited as a recessive trait, and affects 1:3500 live births, especially males. Low-intensity exercise is known to decrease certain parameters associated with muscular degeneration in animal models of progressive muscular dystrophies. In the present study, 28-day-old male mdx and wild-type (wild) mice were used. The animals were subjected to a low-intensity physical exercise protocol for 8 weeks. It was found that this protocol was able to reduce oxidative stress in muscle tissue and in most of the CNS structures analyzed, with a significant increase in antioxidant activity in all analyzed structures. It is thus possible to infer that this exercise protocol was able to reduce oxidative stress and improve the energy metabolism in brain tissue and in the gastrocnemius muscle of animals with DMD.
杜氏肌营养不良症（DMD）是一种由 X 染色体突变引起的疾病，呈隐性遗传，每 3500 例活产儿中就有 1 例患病，尤其好发于男性。低强度运动已知可降低进行性肌营养不良动物模型中与肌肉退化相关的某些参数。在本研究中，使用了 28 天大的雄性 mdx 和野生型（野生）小鼠。这些动物接受了为期 8 周的低强度体育锻炼方案。结果发现，该方案能够降低肌肉组织和大多数分析的中枢神经系统结构中的氧化应激，所有分析结构中的抗氧化活性都显著增加。因此，可以推断该运动方案能够降低 DMD 动物的大脑组织和比目鱼肌中的氧化应激，并改善其能量代谢。
