微小RNA：造血过程中的关键参与者。

microRNAs: Key Players in Hematopoiesis.

作者信息

Raghuwanshi Sanjeev, Karnati Hanuma Kumar, Sarvothaman Shilpa, Gutti Usha, Saladi Raja Gopal Venakata, Tummala Prathibha Reddy, Gutti Ravi Kumar

机构信息

Stem Cells and Haematological Disorders Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, (PO) Gachibowli, Hyderabad, Telangana, 500 046, India.

Department of Biotechnology, GITAM Institute of Science, Gandhi Institute of Technology and Management (GITAM) University, Visakhapatnam, Andhra Pradesh, 530 045, India.

出版信息

Adv Exp Med Biol. 2015;887:171-211. doi: 10.1007/978-3-319-22380-3_10.

DOI:10.1007/978-3-319-22380-3_10

PMID:26662992

Abstract

microRNAs (miRNAs) are small length noncoding RNAs which play a key role in cellular processes such as proliferation, differentiation, and development of lineage hematopoietic cells and matured blood cells. Aberrant expression of miRNAs has been reported in several hematopoietic disorders. The involvement of miRNAs in regulation of various signaling pathways has been shown in hematopoietic disorders. Along with regulatory role, miRNAs are also proven as diagnostic and prognostic markers for these malignancies. Recent studies are evidenced that the miRNA are key regulators of hematopoietic disorders and progression of these disorders shows the importance of targeting the aberrant expression of miRNAs as new therapeutic interventions. The present chapter provides overview of the art related to the importance of miRNAs in developmental hematopoiesis and pathogenesis of hematopoietic disorders including chronic lymphocytic leukemia, chronic myelogenous leukemia, multiple myelomas, and B cell lymphomas.

摘要

微小RNA（miRNA）是长度较短的非编码RNA，在造血细胞系和成熟血细胞的增殖、分化及发育等细胞过程中发挥关键作用。在多种造血系统疾病中均报道有miRNA的异常表达。在造血系统疾病中，miRNA参与多种信号通路的调控已得到证实。除了具有调控作用外，miRNA还被证明是这些恶性肿瘤的诊断和预后标志物。最近的研究表明，miRNA是造血系统疾病的关键调节因子，这些疾病的进展显示了将异常表达的miRNA作为新的治疗靶点的重要性。本章概述了miRNA在发育性造血以及包括慢性淋巴细胞白血病、慢性粒细胞白血病、多发性骨髓瘤和B细胞淋巴瘤在内的造血系统疾病发病机制中的重要性相关的技术。