临床高危精神病个体的各种神经认知缺陷及转化风险。
Various neurocognitive deficits and conversion risk in individuals at clinical high risk for psychosis.
作者信息
Mourik Kees, Decrescenzo Paula, Brucato Gary, Gill Kelly E, Arndt Leigh, Kimhy David, Keilp John G, Girgis Ragy R
机构信息
Department of Psychiatry, New York State Psychiatric Institute, Columbia University, New York, New York, USA.
出版信息
Early Interv Psychiatry. 2017 Jun;11(3):250-254. doi: 10.1111/eip.12296. Epub 2015 Dec 10.
AIM
Individuals at clinical high risk for psychosis (CHR) exhibit neurocognitive deficits in multiple domains. The aim of this study is to investigate whether several components of neurocognition are predictive of conversion to psychosis.
METHODS
Fifty-two CHR individuals were assessed with the Structured Interview for Psychosis Risk Syndromes and completed a battery of neurocognitive tests at baseline including measures of executive functioning, attention, working memory, processing speed and reaction time. Neurocognitive functioning at baseline was scored based on an external normative control group. Most subjects were followed for 2.5 years to determine conversion status.
RESULTS
Significant differences in neurocognitive functioning between CHR individuals and the control group were present in all domains. Twenty-six per cent of the participants converted to psychosis within 9.8 (standard deviation = 8.0) months on average (median 9 months), but there were no significant differences in neurocognition converters and non-converters.
CONCLUSIONS
Individuals at CHR have deficits in neurocognitive functioning, but such deficits do not appear to be related to conversion risk.
目的
临床高危精神病个体（CHR）在多个领域存在神经认知缺陷。本研究旨在调查神经认知的几个组成部分是否可预测向精神病的转化。
方法
对52名CHR个体进行了精神病风险综合征结构化访谈评估，并在基线时完成了一系列神经认知测试，包括执行功能、注意力、工作记忆、处理速度和反应时间的测量。基于外部标准化对照组对基线时的神经认知功能进行评分。大多数受试者随访2.5年以确定转化状态。
结果
CHR个体与对照组在所有领域的神经认知功能均存在显著差异。26%的参与者平均在9.8（标准差=8.0）个月内（中位数9个月）转化为精神病，但神经认知转化者和未转化者之间无显著差异。
结论
CHR个体存在神经认知功能缺陷，但这些缺陷似乎与转化风险无关。
Zotero 插件