Kemnitz J W, Goy R W, Flitsch T J, Lohmiller J J, Robinson J A
Wisconsin Regional Primate Research Center, University of Wisconsin, Madison 53715-1299.
J Clin Endocrinol Metab. 1989 Aug;69(2):287-93. doi: 10.1210/jcem-69-2-287.
Obese (n = 8) and nonobese (n = 6) adult rhesus monkeys (Macaca mulatta) were assessed in terms of body size and distribution of body fat, glucose tolerance, and serum lipid, insulin, and androgen levels. The weights of the obese monkeys were more than 2 SD above the mean for their sex, while the nonobese monkeys averaged less than 0.25 SD from the mean. Obese males and females had excess body fat located predominantly in the abdominal region; abdominal circumference was highly correlated with total body fat, as estimated by the isotope dilution method (r = 0.98; P less than 0.001). Obese monkeys of both sexes had fasting hyperinsulinemia, greater insulin response to iv glucose administration, and marginally impaired glucose tolerance. Obese males had delayed maximal insulin response to glucose administration. Fasting serum triglycerides also were elevated in the obese monkeys (0.95 +/- 0.08 vs. 0.47 +/- 0.05 mmol/L; P less than 0.001). Obese males had lower serum dihydrotestosterone levels than nonobese males (3.1 +/- 0.7 vs. 5.6 +/- 0.4 nmol/L; P less than 0.01). Nonobese females had approximately 2-fold higher serum dehydroepiandrosterone sulfate levels than the other groups. We conclude that obese male and female rhesus monkeys have patterns of fat distribution and glucoregulatory abnormalities similar to those of humans with upper body obesity. The contribution of differences in androgen metabolism to the development of obesity and its complications in rhesus monkeys remain to be defined.
对8只肥胖和6只非肥胖成年恒河猴（猕猴）进行了身体大小、体脂分布、糖耐量以及血脂、胰岛素和雄激素水平的评估。肥胖猴子的体重比其性别平均体重高出2个标准差以上，而非肥胖猴子的体重平均比平均体重低不到0.25个标准差。肥胖的雄性和雌性恒河猴体内多余的体脂主要集中在腹部区域；通过同位素稀释法估算，腹围与总体脂高度相关（r = 0.98；P < 0.001）。两性肥胖猴子均有空腹高胰岛素血症，静脉注射葡萄糖后胰岛素反应增强，糖耐量略有受损。肥胖雄性猴子对葡萄糖注射的最大胰岛素反应延迟。肥胖猴子的空腹血清甘油三酯水平也升高（0.95±0.08 vs. 0.47±0.05 mmol/L；P < 0.001）。肥胖雄性猴子的血清双氢睾酮水平低于非肥胖雄性猴子（3.1±0.7 vs. 5.6±0.4 nmol/L；P < 0.01）。非肥胖雌性猴子的血清硫酸脱氢表雄酮水平比其他组高出约2倍。我们得出结论，肥胖的雄性和雌性恒河猴具有与上身肥胖人类相似的脂肪分布模式和糖调节异常。雄激素代谢差异对恒河猴肥胖及其并发症发展的影响仍有待确定。
