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肉毒杆菌毒素在儿童中的罕见应用成功长期治疗原发性腭震颤

Successful Treatment of Essential Palatal Tremor Lasting Over a Long Term with a Rare Application of Botulinum Toxin in a Child.

作者信息

Eryılmaz Aylin, Başal Yeşim, Günel Ceren, Ozkul Ayca, Tosun Ayşe

机构信息

Department of Otorhinolaryngology Head and Neck Surgery, Adnan Menderes University School of Medicine, Aydın, Turkey.

Department of Neurology Adnan Menderes University School of Medicine, Aydın, Turkey.

出版信息

Iran J Child Neurol. 2015 Fall;9(4):75-7.

Abstract

Objective Essential Palatal Tremor (PT) is a disorder in which radiological brain images appear normal but the clicking noise caused by peritubal, palatal muscle contractions remains the main complaint of patients. The condition occurs rarely in childhood. This paper demonstrates such a rare case with bilateral presentation of essential PT in a 12-yr-old girl could successfully be treated with botulinum toxin therapy at Otorhinolaryngology Department in 2013, as she was still asymptomatic after 16 months. Besides, being minimally invasive with negligible side effects, this choice of treatment with botulinum toxin A (BTA) leads to a long-term symptom free outcome from essential PT.

摘要

目的 特发性腭震颤(PT)是一种疾病,其脑部放射影像显示正常,但咽鼓管周围、腭部肌肉收缩所产生的咔嗒声仍是患者的主要诉求。该病症在儿童时期很少见。本文展示了这样一个罕见病例,一名12岁双侧特发性PT的女孩于2013年在耳鼻喉科接受肉毒杆菌毒素治疗后获得成功,16个月后仍无症状。此外,肉毒杆菌毒素A(BTA)这种治疗选择具有微创性且副作用可忽略不计,能使特发性PT实现长期无症状的治疗效果。

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本文引用的文献

1
Essential palatal tremor treated with botulinum toxin.必要的腭部震颤用肉毒毒素治疗。
Pediatr Neurol. 2013 May;48(5):415-7. doi: 10.1016/j.pediatrneurol.2012.12.035.
6
Palatal tremor in childhood: clinical and therapeutic considerations.儿童腭部震颤:临床与治疗考量
Dev Med Child Neurol. 2006 Dec;48(12):982-4. doi: 10.1017/S0012162206002155.
7
Treatment of essential palatal myoclonus in a 10-year-old girl with botulinum neurotoxin.
Otol Neurotol. 2006 Aug;27(5):672-5. doi: 10.1097/01.mao.0000224085.08344.50.
9
Voluntary control and a wider clinical spectrum of essential palatal tremor.
Mov Disord. 2004 Jun;19(6):717-9. doi: 10.1002/mds.20034.
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Treatment for severe palatoclonus by occlusion of the eustachian tube.
Otol Neurotol. 2003 Sep;24(5):714-6. doi: 10.1097/00129492-200309000-00003.

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