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[前列腺癌诊断中的相关生物标志物]

[Related biomarkers in the diagnosis of prostate cancer].

作者信息

Xu Yi-min, Liu Hai-zhen

出版信息

Zhonghua Nan Ke Xue. 2015 Oct;21(10):937-40.

Abstract

Prostate cancer is one of the most common malignant tumors in the male urinary system as well as the second leading cause of cancer death in men. Prostate specific antigen (PSA) screening is the main method for the early diagnosis of prostate cancer, but has a low specificity for its detection. In recent years, a variety of tumor markers with high sensitivity and specificity have been found. This review focuses on some of the more promising tumor biomarkers such as prostate cancer antigen 3, early prostate cancer antigen, prostate-specific membrane antigen, alpha-methylacyl-CoA racemase, and vascular endothelial growth factor.

摘要

前列腺癌是男性泌尿系统中最常见的恶性肿瘤之一,也是男性癌症死亡的第二大主要原因。前列腺特异性抗原(PSA)筛查是前列腺癌早期诊断的主要方法,但其检测特异性较低。近年来,人们发现了多种具有高灵敏度和特异性的肿瘤标志物。本文综述聚焦于一些更具潜力的肿瘤生物标志物,如前列腺癌抗原3、早期前列腺癌抗原、前列腺特异性膜抗原、α-甲基酰基辅酶A消旋酶和血管内皮生长因子。

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