全基因组关联研究揭示了两个猪群体中与妊娠期长度相关的区域。
Genome-wide association study reveals regions associated with gestation length in two pig populations.
作者信息
Hidalgo A M, Lopes M S, Harlizius B, Bastiaansen J W M
机构信息
Animal Breeding and Genomics Centre, Wageningen University, P.O. Box 338, 6700 AH, Wageningen, the Netherlands.
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 7023, 750 07, Uppsala, Sweden.
出版信息
Anim Genet. 2016 Apr;47(2):223-6. doi: 10.1111/age.12395. Epub 2015 Dec 14.
Reproduction traits, such as gestation length (GLE), play an important role in dam line breeding in pigs. The objective of our study was to identify single nucleotide polymorphisms (SNPs) that are associated with GLE in two pig populations. Genotypes and deregressed breeding values were available for 2081 Dutch Landrace-based (DL) and 2301 Large White-based (LW) pigs. We identified two QTL regions for GLE, one in each population. For DL, three associated SNPs were detected in one QTL region spanning 0.52 Mbp on Sus scrofa chromosome (SSC) 2. For LW, four associated SNPs were detected in one region of 0.14 Mbp on SSC5. The region on SSC2 contains the heparin-binding EGF-like growth factor (HBEGF) gene, which promotes embryo implantation and has been described to be involved in embryo survival throughout gestation. The associated SNP can be used for marker-assisted selection in the studied populations, and further studies of the HBEGF gene are warranted to investigate its role in GLE.
繁殖性状，如妊娠期长度（GLE），在猪的母系育种中起着重要作用。我们研究的目的是在两个猪群中鉴定与GLE相关的单核苷酸多态性（SNP）。有2081头基于荷兰长白猪（DL）和2301头基于大白猪（LW）的猪的基因型和去回归育种值。我们在每个群体中各鉴定出一个与GLE相关的QTL区域。对于DL，在猪1号染色体（SSC）2上一个跨度为0.52兆碱基对的QTL区域中检测到三个相关SNP。对于LW，在SSC5上一个0.14兆碱基对的区域中检测到四个相关SNP。SSC2上的区域包含肝素结合表皮生长因子样生长因子（HBEGF）基因，该基因促进胚胎着床，并且已被描述为在整个妊娠期参与胚胎存活。相关SNP可用于所研究群体的标记辅助选择，并且有必要对HBEGF基因进行进一步研究以调查其在GLE中的作用。
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