Rose Nancy C
Intermountain Healthcare, University of Utah, Salt Lake City, Utah.
Clin Obstet Gynecol. 2016 Mar;59(1):140-7. doi: 10.1097/GRF.0000000000000172.
Obesity compromises all forms of genetic screening. Although the risk for fetal aneuploidy is not altered by obesity, the risk for significant birth defects is increased. Therefore, the obese gravida is at an increased risk of fetal malformations with a diminished ability to be screened effectively by all screening methods: ultrasound, traditional serum analyte screening, and cell-free DNA screening. This chapter outlines both the current options and limitations of screening in the obese gravida. The offering of screening and diagnostic testing should not be altered in obese women despite the compromises placed on accurate fetal assessment.
肥胖会影响所有形式的基因筛查。尽管肥胖不会改变胎儿非整倍体的风险，但严重出生缺陷的风险会增加。因此，肥胖孕妇发生胎儿畸形的风险增加，而通过所有筛查方法（超声、传统血清分析物筛查和游离DNA筛查）进行有效筛查的能力下降。本章概述了肥胖孕妇筛查的当前选择和局限性。尽管准确的胎儿评估受到影响，但肥胖女性的筛查和诊断检测服务不应改变。
