Hansen Jakob W, Thomsen Simon F, Porsbjerg Celeste, Rasmussen Linda M, Harmsen Lotte, Johansen Julia S, Backer Vibeke
Department of Respiratory Medicine, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark;
Department of Respiratory Medicine, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
Eur Clin Respir J. 2015 Sep 16;2:25117. doi: 10.3402/ecrj.v2.25117. eCollection 2015.
Studies have shown a relationship between asthma, serum YKL-40, and the single nucleotide polymorphism (SNP) (-131 C/G, rs4950928) in the CHI3L1 gene that codes for YKL-40. However, the findings differ. We studied the relationship between clinical asthma phenotypes, serum YKL-40, and SNP (-131 C/G, rs4950928).
In this study, 1,137 patients with asthma, 415 with rhinitis only, and 275 non-asthmatic controls were included. Assessment included a clinical interview concerning the diagnosis of asthma, severity of asthma, and asthma treatment as well as clinical tests to assess asthma and rhinitis. Serum YKL-40 was measured, and genotyping for the SNP (-131 C/G) was conducted.
No significant difference in the serum concentration of YKL-40 was found between patients with asthma, patients with rhinitis, and non-asthmatic controls; however, YKL-40 was increased in patients with severe asthma. No association was found between the SNP (-131 C/G rs4950982) and the risk of having asthma (odds ratio = 0.90, p=0.4). Higher levels of serum YKL-40 were found in all subjects when comparing CC genotype to CG and GG genotypes (45 µg/L vs. 32 µg/L and 19 µg/L, p<0.0001).
There was no association between polymorphisms of SNP (-131 C/G) and asthma. The highest serum YKL-40 concentrations were seen in severe asthmatics. Individuals with less severe asthma showed a smaller difference against controls, limiting its clinical usefulness. More research is needed to clarify the relationship between different asthma phenotypes, YKL-40, and CHI3L1.
研究表明哮喘、血清YKL-40与编码YKL-40的CHI3L1基因中的单核苷酸多态性（SNP）（-131 C/G，rs4950928）之间存在关联。然而，研究结果存在差异。我们研究了临床哮喘表型、血清YKL-40与SNP（-131 C/G，rs4950928）之间的关系。
本研究纳入了1137例哮喘患者、415例仅患有鼻炎的患者和275例非哮喘对照者。评估包括关于哮喘诊断、哮喘严重程度和哮喘治疗的临床访谈以及评估哮喘和鼻炎的临床检查。检测血清YKL-40，并对SNP（-131 C/G）进行基因分型。
哮喘患者、鼻炎患者和非哮喘对照者之间的血清YKL-40浓度无显著差异；然而，重度哮喘患者的YKL-40升高。未发现SNP（-131 C/G rs495,0982）与患哮喘风险之间存在关联（比值比 = 0.90，p = 0.4）。与CG和GG基因型相比，CC基因型的所有受试者血清YKL-40水平更高（45 μg/L对32 μg/L和19 μg/L，p < 0.0001）。
SNP（-131 C/G）多态性与哮喘之间无关联。重度哮喘患者的血清YKL-40浓度最高。哮喘较轻的个体与对照者之间的差异较小，限制了其临床应用价值。需要更多研究来阐明不同哮喘表型、YKL-40和CHI3L1之间的关系。
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