CHI3L1 基因的遗传变异与支气管哮喘有关。

A genetic variation in CHI3L1 is associated with bronchial asthma.

机构信息

Department of ICU, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.

Department of Respiratory Diseases, Nanfang Hospital, Guangzhou, China.

出版信息

Arch Physiol Biochem. 2021 Jun;127(3):279-284. doi: 10.1080/13813455.2019.1634737. Epub 2019 Jul 11.

DOI:10.1080/13813455.2019.1634737

PMID:31295039

Abstract

BACKGROUND

This study was aimed to investigate the associations among Chitinase 3-like 1 ( polymorphisms, asthma and plasma YKL-40 levels in Chinese population.

MATERIAL AND METHODS

Four single nucleotide polymorphisms (SNPs) were genotyped. The YKL-40 level in plasma and eosinophil percentage in peripheral blood were quantified.

RESULTS

A SNP (rs4950928) in the promoter was associated with elevated plasma YKL-40 levels ( = .02), asthma ( = .042) and lung function ( = .029 to .002) in this Chinese population. Plasma YKL-40 levels were significantly elevated in patients with asthma compared to those in control subjects ( < .05). Plasma YKL-40 levels were significantly correlated with forced expiratory volume per cent (FEV1%) measurements ( < .05). Although plasma YKL-40 levels were decreased after treatment, the correlation with FEV1% still existed.

CONCLUSIONS

locus is a risk factor for asthma in Chinese population.

摘要

背景

本研究旨在探讨中国人群几丁质酶 3 样蛋白 1（多态性、哮喘和血浆 YKL-40 水平之间的关联。

材料与方法

对 4 个单核苷酸多态性（SNP）进行基因分型。定量检测血浆中 YKL-40 水平和外周血嗜酸性粒细胞百分比。

结果

在中国人群中，启动子中的一个 SNP（rs4950928）与血浆 YKL-40 水平升高（ = .02）、哮喘（ = .042）和肺功能（ = .029 至.002）有关。与对照组相比，哮喘患者的血浆 YKL-40 水平显著升高（ < .05）。血浆 YKL-40 水平与用力呼气量百分比（FEV1%）呈显著相关性（ < .05）。尽管治疗后血浆 YKL-40 水平降低，但与 FEV1% 的相关性仍然存在。