德国非黑素瘤皮肤癌的存活率。
Survival with nonmelanoma skin cancer in Germany.
机构信息
Institute of Social Medicine and Epidemiology, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
出版信息
Br J Dermatol. 2016 Apr;174(4):778-85. doi: 10.1111/bjd.14352. Epub 2016 Mar 22.
BACKGROUND
Nonmelanoma skin cancer (NMSC) is the most common cancer in Germany, but detailed information on survival is lacking.
OBJECTIVES
To provide survival estimates for female and male patients with basal cell carcinoma (BCC), squamous cell carcinoma (SCC), sarcoma, adenocarcinoma and Merkel cell carcinoma. Further subgroup analyses were carried out by age, tumour stage and body site.
METHODS
In total 459 640 patients diagnosed with NMSC in 1997-2011 were included from population-based cancer registers, covering a population of 33 million inhabitants. Age-standardized absolute and relative 5-year and 10-year survival were calculated using period analysis.
RESULTS
The absolute and relative 5-year survival were 87·1% and 102·9% for BCC, 77·6% and 93·6% for SCC, 82·1% and 96·0% for sarcoma, 71·4% and 85·7% for adenocarcinoma and 60·0% and 70·7% for Merkel cell carcinoma, respectively. Higher age, female sex and advanced stage were associated with lower survival.
CONCLUSIONS
A comprehensive overview of NMSC survival in Germany is provided. The differences between the NMSC subtypes require a more differentiated consideration of patient survival. The survival advantage of patients with BCC may be related to health-promoting factors related to the BCC diagnosis, such as changes to a healthier lifestyle.
背景
非黑色素瘤皮肤癌（NMSC）是德国最常见的癌症，但有关生存的详细信息尚不清楚。
目的
提供基底细胞癌（BCC）、鳞状细胞癌（SCC）、肉瘤、腺癌和 Merkel 细胞癌女性和男性患者的生存估计。进一步通过年龄、肿瘤分期和身体部位进行亚组分析。
方法
从基于人群的癌症登记处共纳入 1997 年至 2011 年间诊断为 NMSC 的 459640 例患者，涵盖了 3300 万居民。使用时期分析计算年龄标准化的绝对和相对 5 年和 10 年生存率。
结果
BCC 的绝对和相对 5 年生存率分别为 87.1%和 102.9%，SCC 为 77.6%和 93.6%，肉瘤为 82.1%和 96.0%，腺癌为 71.4%和 85.7%，Merkel 细胞癌为 60.0%和 70.7%。年龄较大、女性和晚期肿瘤与生存率降低相关。
结论
提供了德国 NMSC 生存的全面概述。NMSC 亚型之间的差异需要更详细地考虑患者的生存情况。BCC 患者的生存优势可能与与 BCC 诊断相关的促进健康的因素有关，例如生活方式的改变。
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