Rudolph Christiane, Schnoor Maike, Eisemann Nora, Katalinic Alexander
Institute of Cancer Epidemiology, University of Luebeck, Luebeck, Germany.
Institute of Social Medicine and Epidemiology, University of Luebeck, Luebeck, Germany.
J Dtsch Dermatol Ges. 2015 Aug;13(8):788-97. doi: 10.1111/ddg.12690.
Nonmelanoma skin cancer (NMSC) is the most common malignant neoplasm in Germany. However, little is known about incidence trends of NMSC and its main subtypes basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) in Germany.
Cancer registry data from fourteen German federal states was used to estimate age-standardized incidence rates by histologic subtype. Annual percentage changes (APC) were estimated in joinpoint regression models, in order to assess trend shifts in the years from 1998 to 2010.
In Germany, incidence rates of NMSC showed a significant increase from 43.1 cases/100 000 in 1998 to 105.2 cases/100 000 in 2010. Incidence rates and incidence increases revealed large regional variations. Basal cell carcinoma was the most common tumor followed by SCC. Men were more frequently affected than women, but incidence increases were steeper in women.
Results are consistent with national and international observations. The heterogeneity of incidence rates and their changes among federal states indicate that incidence changes are most likely related to improved case registration practices in German cancer registries.
非黑色素瘤皮肤癌（NMSC）是德国最常见的恶性肿瘤。然而，关于德国NMSC及其主要亚型基底细胞癌（BCC）和鳞状细胞癌（SCC）的发病率趋势，人们知之甚少。
利用来自德国14个联邦州的癌症登记数据，按组织学亚型估计年龄标准化发病率。通过连接点回归模型估计年度百分比变化（APC），以评估1998年至2010年期间的趋势变化。
在德国，NMSC的发病率从1998年的43.1例/10万显著增加到2010年的105.2例/10万。发病率及发病率增长存在很大的地区差异。基底细胞癌是最常见的肿瘤，其次是鳞状细胞癌。男性比女性更易患病，但女性的发病率增长更为陡峭。
结果与国内和国际观察结果一致。发病率及其在各联邦州之间变化的异质性表明，发病率变化很可能与德国癌症登记处病例登记做法的改进有关。
