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局部进展期直肠癌伴会阴部坏死性筋膜炎:早期积极手术及多模式治疗取得成功

Locally advanced adenocarcinoma of the rectum presenting with necrotising fasciitis of the perineum: successful management with early aggressive surgery and multimodal therapy.

作者信息

Ferreira Luís, Alexandrino Henrique, Soares Leite Júlio, Castro Sousa Francisco

机构信息

Department of Surgery A, Hospitais da Universidade de Coimbra, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Department of Surgery A, Hospitais da Universidade de Coimbra, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal Faculty of Medicine, Clinica Universitária Cirurgia III, University of Coimbra, Coimbra, Portugal.

出版信息

BMJ Case Rep. 2015 Dec 16;2015:bcr2015213245. doi: 10.1136/bcr-2015-213245.

Abstract

Colorectal cancer is a common malignant neoplasm and its treatment usually involves surgery associated, in some cases, depending on the staging, with chemoradiotherapy. Necrotising fasciitis of the perineum is a highly lethal infection of the perineum, perirectal tissues and genitals, requiring emergency surgical debridement, broad-spectrum antibiotics and control of sepsis. We present the case of a 59-year-old man with necrotising fasciitis of the perineum as the first clinical manifestation of locally advanced adenocarcinoma of the rectum, in which successful management consisted of early and aggressive surgical debridement, followed by multimodal therapy with curative intent. 2 years and 6 months after surgery the patient is well, with no evidence of local or systemic relapse.

摘要

结直肠癌是一种常见的恶性肿瘤,其治疗通常包括手术,在某些情况下,根据分期还需联合放化疗。会阴坏死性筋膜炎是一种发生于会阴、直肠周围组织和生殖器的高致死性感染,需要紧急手术清创、使用广谱抗生素并控制脓毒症。我们报告一例59岁男性患者,其会阴坏死性筋膜炎是局部晚期直肠癌的首发临床表现,成功的治疗方法包括早期积极的手术清创,随后进行根治性多模式治疗。术后2年6个月,患者情况良好,无局部或全身复发迹象。

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