冠状动脉血流缓慢患者血清脯氨酰二肽氨基肽酶活性的评估。

Evaluation of serum prolidase activity in patients with slow coronary flow.

作者信息

Suner Arif, Nurdag Abdullah, Polat Mustafa, Kaya Hakan, Koroglu Sedat, Acar Gurkan, Sezen Hatice

机构信息

Cardiology Department, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey.

Cardiology Department, Balikligol State Hospital, Sanliurfa, Turkey.

出版信息

Postepy Kardiol Interwencyjnej. 2015;11(3):206-11. doi: 10.5114/pwki.2015.54015. Epub 2015 Sep 28.

DOI:10.5114/pwki.2015.54015

PMID:26677361

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4631735/

Abstract

INTRODUCTION

Slow coronary flow (SCF) is described as the slow passage of contrast to distal coronaries despite anatomically normal coronary arteries. It has been shown that increased serum prolidase activity (SPA) correlates with collagen turnover. Increased collagen turnover might be associated with the development of atherosclerotic plaques.

AIM

To investigate the relationship between serum prolidase activity and slow coronary flow.

MATERIAL AND METHODS

This cross-sectional study included 40 SCF patients (mean age: 55.0 ±9.5 years, 20 females) and 40 controls (mean age: 53.9 ±8.2 years, 21 females) with normal coronary anatomy and normal coronary flow. The Thrombolysis in Myocardial Infarction (TIMI) frame-count (TFC) method was used for SCF diagnosis. Serum prolidase activity was measured spectrophotometrically, and the relevant parameters were compared between the groups.

RESULTS

There were no statistically significant differences between the SCF and control groups in terms of basic demographic, clinical, and laboratory data. However, the SPA was significantly higher in the SCF group compared to the control (702.7 ±13.8 and 683.9 ±13.2 respectively, p<0.001). Serum prolidase activity was significantly correlated with the mean TFC (r=0.463, p<0.001). The overall findings of this study support the predictive accuracy of the serum prolidase activity in our cohort, with a statistically significant ROC value of 681.3.

CONCLUSIONS

Our study showed that SPA was increased in SCF patients. The activity of this enzyme was significantly correlated with the mean TFC.

摘要

引言

尽管冠状动脉解剖结构正常，但冠状动脉血流缓慢（SCF）被描述为造影剂向冠状动脉远端的缓慢通过。研究表明，血清脯氨酰肽酶活性（SPA）升高与胶原蛋白周转相关。胶原蛋白周转增加可能与动脉粥样硬化斑块的形成有关。

目的

研究血清脯氨酰肽酶活性与冠状动脉血流缓慢之间的关系。

材料与方法

这项横断面研究纳入了40例冠状动脉血流缓慢患者（平均年龄：55.0±9.5岁，20例女性）和40例冠状动脉解剖结构正常且冠状动脉血流正常的对照组（平均年龄：53.9±8.2岁，21例女性）。采用心肌梗死溶栓（TIMI）帧数（TFC）法诊断冠状动脉血流缓慢。用分光光度法测量血清脯氨酰肽酶活性，并比较两组的相关参数。

结果

冠状动脉血流缓慢组和对照组在基本人口统计学、临床和实验室数据方面无统计学显著差异。然而，冠状动脉血流缓慢组的血清脯氨酰肽酶活性显著高于对照组（分别为702.7±13.8和683.9±13.2，p<0.001）。血清脯氨酰肽酶活性与平均TFC显著相关（r=0.463，p<0.001）。本研究的总体结果支持血清脯氨酰肽酶活性在我们队列中的预测准确性，ROC值为681.3，具有统计学显著性。