Aktürk Erdal, Aşkın Lütfü, Nacar Hüseyin, Taşolar M Hakan, Türkmen Serdar, Çetin Mustafa, Bozkurt Mehmet
Department of Cardiology, Adıyaman University Training and Research Hospital; Adıyaman-Turkey.
Anatol J Cardiol. 2018 Feb;19(2):110-116. doi: 10.14744/AnatolJCardiol.2017.8160. Epub 2018 Jan 17.
Coronary artery ectasia (CAE) is defined as an angiographic enlargement of a portion of the coronary artery between 1.5 and 2 times the diameter of the adjacent normal coronary artery. It has been demonstrated that increased serum prolidase activity (SPA) is associated with increased collagen turnover. We aimed to analyze the relationship between CAE and serum SPA levels.
This study used a prospective case protocol design. A total of 40 consecutive patients with isolated right CAE and normal coronary arteries (23 men, 17 women; mean age, 62.4±10.8 years) were evaluated. The control group included the same number of consecutive patients with angiographically normal coronary arteries (20 men, 20 women; mean age, 63.8±11.1 years). Clinical characteristics, laboratory results, cardiovascular risk factors, and medication use were recorded. SPA was measured using a spectrophotometer. Student's t-test, Mann-Whitney U test, chi-square test, Pearson's and Spearman's correlations, logistic regression analysis, and ROC curve analysis were used for statistical analysis.
SPA was significantly higher in the CAE group compared with the control group (1635.2±492.0 U/L and 986.2±422.3 U/L, respectively; p<0.001). The relationship of SPA with CAE proved to be significant (r=0.512; p<0.001). SPA also served as an independent predictor of CAE (OR=1.003; 95% CI, 1.001-1.005; p=0.002). The SPA value of 1170 U/L was predictive of CAE, with a sensitivity of 85% and specificity of 60% (AUC=0.854; 95% CI, 0.763-0.944; p<0.001).
The activity of this enzyme was significantly correlated with CAE.
冠状动脉扩张（CAE）被定义为冠状动脉某一部分在血管造影上的扩张，其直径是相邻正常冠状动脉直径的1.5至2倍。已有研究表明，血清脯氨酰二肽氨基肽酶活性（SPA）升高与胶原蛋白周转增加有关。我们旨在分析CAE与血清SPA水平之间的关系。
本研究采用前瞻性病例方案设计。共评估了40例连续的孤立性右冠状动脉扩张且冠状动脉正常的患者（23例男性，17例女性；平均年龄62.4±10.8岁）。对照组包括相同数量的连续冠状动脉血管造影正常的患者（20例男性，20例女性；平均年龄63.8±11.1岁）。记录临床特征、实验室检查结果、心血管危险因素和用药情况。使用分光光度计测量SPA。采用学生t检验、曼-惠特尼U检验、卡方检验、皮尔逊和斯皮尔曼相关性分析、逻辑回归分析和ROC曲线分析进行统计分析。
CAE组的SPA显著高于对照组（分别为1635.2±492.0 U/L和986.2±422.3 U/L；p<0.001）。SPA与CAE的关系被证明具有显著性（r=0.512；p<0.001）。SPA也是CAE的独立预测因子（OR=1.003；95%CI，1.001-1.005；p=0.002）。SPA值为1170 U/L可预测CAE，敏感性为85%，特异性为60%（AUC=0.854；95%CI，0.763-0.944；p<0.001）。
该酶的活性与CAE显著相关。
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