Huang Ling, Langerak Anton W, Wolvers-Tettero Ingrid L M, Meijers Ruud W J, Baan Carla C, Litjens Nicolle H R, Betjes Michiel G H
Department of Internal Medicine, Section Nephrology and Transplantation, Erasmus University Medical Center, Room NA-523, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.
Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Immun Ageing. 2015 Dec 14;12:28. doi: 10.1186/s12979-015-0055-7. eCollection 2015.
End stage renal disease (ESRD) is associated with defective T-cell mediated immunity. A diverse T-cell receptor (TCR) Vβ repertoire is central to effective T-cell mediated immune responses to foreign antigens. In this study, the effect of ESRD on TCR Vβ repertoire was assessed.
A higher proportion of ESRD patients (68.9 %) had a skewed TCR Vβ repertoire compared to age and cytomegalovirus (CMV) - IgG serostatus matched healthy individuals (31.4 %, P < 0.001). Age, CMV serostatus and ESRD were independently associated with an increase in shifting of the TCR Vβ repertoire. More differentiated CD8(+) T cells were observed in young ESRD patients with a shifted TCR Vβ repertoire. CD31-expressing naive T cells and relative telomere length of T cells were not significantly related to TCR Vβ skewing.
ESRD significantly skewed the TCR Vβ repertoire particularly in the elderly population, which may contribute to the uremia-associated defect in T-cell mediated immunity.
终末期肾病（ESRD）与T细胞介导的免疫功能缺陷相关。多样的T细胞受体（TCR）Vβ库对于对外源抗原产生有效的T细胞介导免疫反应至关重要。在本研究中，评估了ESRD对TCR Vβ库的影响。
与年龄和巨细胞病毒（CMV）-IgG血清状态匹配的健康个体相比，更高比例的ESRD患者（68.9%）存在TCR Vβ库偏移（31.4%，P<0.001）。年龄、CMV血清状态和ESRD与TCR Vβ库偏移增加独立相关。在TCR Vβ库发生偏移的年轻ESRD患者中观察到更多分化的CD8(+) T细胞。表达CD31的初始T细胞和T细胞的相对端粒长度与TCR Vβ偏移无显著相关性。
ESRD显著使TCR Vβ库发生偏移，尤其是在老年人群中，这可能导致与尿毒症相关的T细胞介导免疫缺陷。
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