综述：Rho GTP酶在乳腺发育、肿瘤发生和转移中的功能的小鼠模型
Minireview: Mouse Models of Rho GTPase Function in Mammary Gland Development, Tumorigenesis, and Metastasis.
作者信息
Zuo Yan, Oh Wonkyung, Ulu Arzu, Frost Jeffrey A
机构信息
Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, Texas 77030.
出版信息
Mol Endocrinol. 2016 Mar;30(3):278-89. doi: 10.1210/me.2015-1294. Epub 2015 Dec 17.
Abstract
Ras homolog (Rho) family small GTPases are critical regulators of actin cytoskeletal organization, cell motility, proliferation, and survival. Surprisingly, the large majority of the studies underlying our knowledge of Rho protein function have been carried out in cultured cells, and it is only recently that researchers have begun to assess Rho GTPase regulation and function in vivo. The purpose of this review is to evaluate our current knowledge of Rho GTPase function in mouse mammary gland development, tumorigenesis and metastasis. Although our knowledge is still incomplete, these studies are already uncovering important themes as to the physiological roles of Rho GTPase signaling in normal mammary gland development and function. Essential contributions of Rho proteins to breast cancer initiation, tumor progression, and metastatic dissemination have also been identified.
摘要
Ras同源物（Rho）家族小GTP酶是肌动蛋白细胞骨架组织、细胞运动、增殖和存活的关键调节因子。令人惊讶的是，我们对Rho蛋白功能的了解大多基于在培养细胞中进行的研究，直到最近研究人员才开始评估Rho GTP酶在体内的调节和功能。本综述的目的是评估我们目前对Rho GTP酶在小鼠乳腺发育、肿瘤发生和转移中的功能的了解。尽管我们的知识仍不完整，但这些研究已经揭示了Rho GTP酶信号在正常乳腺发育和功能中的生理作用的重要主题。Rho蛋白对乳腺癌起始、肿瘤进展和转移扩散的重要贡献也已得到确认。
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