Sun Hongzhao, Zhang Jing, Shi Yuan, Gao Yan, Shi Guiyan, Wang Xin, Guo Peng, Huang Yu, Ren Yuning, Zheng Shan
College of Life Science, Qi Lu Normal University, Jinan, China.
J Gastroenterol Hepatol. 2016 Jul;31(7):1280-3. doi: 10.1111/jgh.13269.
H2 S is an important gasotransmitter in the gastrointestinal tract. The aim of the present study was to investigate the effect of exogenous H2 S on gastric acid secretion.
Male Wistar rats were randomly divided into physiological saline (PS) group, sodium hydrosulfide (NaHS; 50, 100, and 150 µmol/kg body weight) group, glibenclamide + NaHS group, and SQ22536 + NaHS group. PH of gastric juice before injection and after injection were determined by a PH meter.
The results showed that NaHS, an exogenous H2 S donor, injected into the enterocoelia significantly reduced the PH of gastric juice, the same volume of PS administered similarly did not change PH of gastric juice, the promotional effect of NaHS on gastric acid secretion could be abolished by glibenclamide, an ATP-sensitive potassium channel K(ATP) blocker SQ22536, an inhibitor of adenyl cyclase.
The data from these experiments suggest that exogenous H2 S promoted gastric acid secretion, which may occur via K(ATP) channels and activate AC-cAMP pathway.
硫化氢是胃肠道中一种重要的气体递质。本研究旨在探讨外源性硫化氢对胃酸分泌的影响。
将雄性Wistar大鼠随机分为生理盐水（PS）组、硫氢化钠（NaHS；50、100和150 μmol/kg体重）组、格列本脲+NaHS组和SQ22536+NaHS组。用pH计测定注射前后胃液的pH值。
结果显示，向腹腔内注射外源性硫化氢供体NaHS可显著降低胃液的pH值，同样注射相同体积的PS则不会改变胃液的pH值，NaHS对胃酸分泌的促进作用可被ATP敏感性钾通道K(ATP)阻滞剂格列本脲、腺苷酸环化酶抑制剂SQ22536消除。
这些实验数据表明，外源性硫化氢促进胃酸分泌，其可能通过K(ATP)通道并激活AC-cAMP途径发生。
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