Lu R K
Zhonghua Fu Chan Ke Za Zhi. 1989 Jan;24(1):26-8, 58.
Thirty-eight healthy female volunteers, aged 26-38 years with regular menstrual cycles entered into a clinical trial for contraception with Chinese made superactive stimulatory analog of LRH i.e., (D-Ala, des-GLY-EA10)-LRH yielding luteolysis. LRH-A 1 mg a day was administered by intranasal spray from the 15th through 25th day of the menstrual cycle for 1-12 consecutive cycles. During LRH-A administration no additional contraceptive was used. Luteolysis refers to reduction in plasma progesterone and shortening of the luteal phase. The results showed that luteolysis occurred in 154/158 cycles, 4 pregnancies occurred due to faulty administration. No severe side-effects were observed during administration and apparently normal cycles occurred immediately after the withdrawal of LRH-A spray. The above data indicated that LRH-A may provide a fairly good luteolytic effect. More intensive study is required for clinical application in contraceptive practice.
38名年龄在26至38岁之间、月经周期规律的健康女性志愿者参加了一项使用国产超活性促黄体生成素释放激素（LRH）类似物即（D-丙氨酸，去甘氨酸-乙基酰胺10）-LRH进行避孕的临床试验，该类似物可导致黄体溶解。从月经周期的第15天至25天，每天通过鼻喷雾剂给予1毫克LRH-A，连续给药1至12个周期。在给予LRH-A期间，未使用其他避孕措施。黄体溶解是指血浆孕酮水平降低和黄体期缩短。结果显示，在158个周期中有154个周期发生了黄体溶解，4例怀孕是由于给药不当所致。给药期间未观察到严重副作用，停用LRH-A喷雾剂后月经周期立即恢复正常。上述数据表明，LRH-A可能具有相当好的黄体溶解作用。在避孕实践中的临床应用还需要更深入的研究。
