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前庭神经鞘瘤的外科治疗。420例病例回顾。

Surgical treatment of vestibular schwannoma. Review of 420 cases.

作者信息

Arístegui Ruiz Miguel Ángel, González-Orús Álvarez-Morujo Ricardo José, Oviedo Carlos Martín, Ruiz-Juretschke Fernando, García Leal Roberto, Scola Yurrita Bartolomé

机构信息

Servicio de ORL, Hospital General Universitario Gregorio Marañón, Madrid, España.

Servicio de ORL, Hospital General Universitario Gregorio Marañón, Madrid, España.

出版信息

Acta Otorrinolaringol Esp. 2016 Jul-Aug;67(4):201-11. doi: 10.1016/j.otorri.2015.09.003. Epub 2015 Dec 8.

Abstract

INTRODUCTION AND OBJECTIVES

Vestibular schwannoma is the most frequent cerebellopontine angle tumor. The aim of our study is to reflect our experience in the surgical treatment of this tumor

MATERIAL AND METHODS

Retrospective study of 420 vestibular schwannomas operated in our hospital between 1994-2014. We include tumor size, preoperative hearing, surgical approaches, definitive facial and hearing functional results, and complications due to surgery.

RESULTS

A total of 417 patients with 420 tumors were analyzed, 209 female (50.1%) and 208 male (49.9%). Mean age at diagnosis was 49.8±13.2 years. The majority of the tumors were resected through a translabyrinthine approach (80.2%). Total tumor removal was achieved in 411 tumors (98.3%), and anatomic preservation of facial nerve in 404 (96.2%). Definitive facial nerve outcome was House-Brackmann grade I and II in 69.9%, and was significantly better in tumors under 20mm. Surgical complications included cerebrospinal fluid leakage in 3 patients (0.7%) and retroauricular subcutaneous collection in 16 (3.8%), 5 cases of meningitis (1.2%), 4 patients with intracraneal bleeding (0.9%), and death in 3 patients (0.7%).

CONCLUSIONS

Surgery is the treatment of choice for vestibular schwannoma in the majority of patients. In our experience, the complication rate is very low and tumor size is the main factor influencing postoperative facial nerve function.

摘要

引言与目的

前庭神经鞘瘤是最常见的桥小脑角肿瘤。本研究的目的是反映我们在该肿瘤手术治疗方面的经验。

材料与方法

对1994年至2014年间在我院接受手术的420例前庭神经鞘瘤进行回顾性研究。我们纳入了肿瘤大小、术前听力、手术入路、最终的面部和听力功能结果以及手术并发症。

结果

共分析了417例患者的420个肿瘤,其中女性209例(50.1%),男性208例(49.9%)。诊断时的平均年龄为49.8±13.2岁。大多数肿瘤通过经迷路入路切除(80.2%)。411个肿瘤(98.3%)实现了肿瘤全切,404个肿瘤(96.2%)面神经解剖保留。最终面神经结果为House-Brackmann I级和II级的占69.9%,在20mm以下的肿瘤中明显更好。手术并发症包括3例脑脊液漏(0.7%)、16例耳后皮下积液(3.8%)、5例脑膜炎(1.2%)、4例颅内出血(0.9%),3例死亡(0.7%)。

结论

手术是大多数前庭神经鞘瘤患者的首选治疗方法。根据我们的经验,并发症发生率非常低,肿瘤大小是影响术后面神经功能的主要因素。

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