Cancer Res Treat. 2003 Apr;35(2):123-9. doi: 10.4143/crt.2003.35.2.123.
This study was performed to estimate the response rate and toxicity of a combination chemotherapy, which included infusional 5-Fluorouracil, Leucovorin and Docetaxel in the treatment of patients with an advanced gastric carcinoma.
Twenty two advanced gastric cancer patients, with a bidimensionally measurable or an evaluable disease, were enrolled in this study. The patients received a 5-fluorouracil 1, 000 mg/m2 intravenous (IV) 24 hour infusion (Day 13), leucovorin 20 mg/m2 (Day 13) and docetaxel 75 mg/m2 intravenously (Day 2) every 3 weeks.
The overall response rate was 45.0%. The median duration of response was 10.0 weeks (range: 424), the median time to response was 8 weeks (range: 820) the median time to progression was 30.0 weeks (95% CI: 16.343.2) and the median overall survival duration was 36.0 weeks (95% CI: 1.770.2). The median cumulative dose of 5-fluorouracil were 316.2 mg/m2/week and docetaxel was 23.9 mg/m2/week. WHO grade III, IV neutropenia, thromocytopenia and anemia occurred in 50.0%, 4.5% and 4.5% of patients, respectively. There were no occurrence of WHO grade III and IV nausea, vomiting, mucositis, conspitation, diarrhea, or neurotoxicity.
This chemotherapy regimen, including infusional 5-fluorouracil, leucovorin and docetaxel was an active agent against advanced gastric cancer patients, especially for previous chemotherapy naive patients.
本研究旨在评估包含氟尿嘧啶持续输注、亚叶酸钙和多西紫杉醇的联合化疗方案治疗晚期胃癌患者的缓解率和毒性。
本研究共纳入 22 例有可测量或可评估疾病的晚期胃癌患者。患者接受氟尿嘧啶 1000mg/m2 静脉输注（第 13 天，24 小时持续）、亚叶酸钙 20mg/m2（第 13 天）和多西紫杉醇 75mg/m2 静脉注射（第 2 天），每 3 周 1 次。
总缓解率为 45.0%。中位缓解持续时间为 10.0 周（范围：424），中位缓解时间为 8 周（范围：820），中位进展时间为 30.0 周（95%CI：16.343.2），中位总生存时间为 36.0 周（95%CI：1.770.2）。氟尿嘧啶的中位累积剂量为 316.2mg/m2/周，多西紫杉醇的中位累积剂量为 23.9mg/m2/周。WHO 分级 III、IV 级中性粒细胞减少、血小板减少和贫血的发生率分别为 50.0%、4.5%和 4.5%。未发生 WHO 分级 III、IV 级恶心、呕吐、黏膜炎、便秘、腹泻或神经毒性。
该化疗方案（包括氟尿嘧啶持续输注、亚叶酸钙和多西紫杉醇）对晚期胃癌患者，尤其是既往未接受化疗的患者，是一种有效的治疗药物。
